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Literature summary for 3.4.21.B40 extracted from

  • Kikkawa, Y.; Yamanaka, N.; Tada, J.; Kanamori, N.; Tsumura, K.; Hosoi, K.
    Prorenin processing and restricted endoproteolysis by mouse tissue kallikrein family enzymes (mK1, mK9, mK13, and mK22) (1998), Biochim. Biophys. Acta, 1382, 55-64.
    View publication on PubMed
Search for more literature for 3.4.21.B40

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
polypeptide + H2O Mus musculus
-
 peptides
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 8-10 weeks old male ICR mice
-

Purification (Commentary)

Purification (Comment) Organism
-
 Mus musculus

Reaction

Reaction Comment Organism Reaction ID
proteolytic cleavage of polypeptides, preferential cleavage site at paired basic amino acid residues preference for Xaa-Arg-Arg- motif Mus musculus
a

Source Tissue

Source Tissue Comment Organism Textmining
submandibular gland
-
 Mus musculus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.0005
-
 purified enzyme, substrate Pyr-Arg-Tyr-Lys-Arg-4-methyl-coumaryl-7-amide Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
benzyloxycarbonyl-Arg-Val-Arg-Arg-4-methyl-coumaryl-7-amide + H2O low activity Mus musculus benzyloxycarbonyl-Arg-Val-Arg-Arg + 7-amino-4-methylcoumarin
-
 ?
benzyloxycarbonyl-Gln-Arg-Arg-4-methyl-coumaryl-7-amide + H2O
-
 Mus musculus benzyloxycarbonyl-Gln-Arg-Arg + 7-amino-4-methylcoumarin
-
 ?
benzyloxycarbonyl-Glu-Lys-Lys-4-methyl-coumaryl-7-amide + H2O low activity Mus musculus benzyloxycarbonyl-Glu-Lys-Lys + 7-amino-4-methylcoumarin
-
 ?
benzyloxycarbonyl-Leu-Lys-Arg-4-methyl-coumaryl-7-amide + H2O
-
 Mus musculus benzyloxycarbonyl-Leu-Lys-Arg + 7-amino-4-methylcoumarin
-
 ?
polypeptide + H2O
-
 Mus musculus peptides
-
 ?
prorenin 2 + H2O recombinant substrate, enzymatically inactive proform Mus musculus renin 2 + ? product is the enzymatically active enzyme form ?
prorenin 2 + H2O specific for mouse prorenin 2 from submandibular gland Mus musculus renin 2 + ? product is the enzymatically active enzyme form ?
Pyr-Arg-Tyr-Lys-Arg-4-methyl-coumaryl-7-amide + H2O best substrate Mus musculus Pyr-Arg-Tyr-Lys-Arg + 7-amino-4-methylcoumarin
-
 ?

Synonyms

Synonyms Comment Organism
EGF-binding protein
-
 Mus musculus
K9
-
 Mus musculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 assay at Mus musculus