Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.21.B26 extracted from

  • Paule, S.; Nebl, T.; Webb, A.; Vollenhoven, B.; Rombauts, L.; Nie, G.
    Proprotein convertase 5/6 cleaves platelet-derived growth factor A in the human endometrium in preparation for embryo implantation (2014), Mol. Hum. Reprod., 21, 262-270.
    View publication on PubMed
Search for more literature for 3.4.21.B26

Protein Variants

Protein Variants Comment Organism
additional information knockout of the enzyme by siRNA Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
proform platelet-derived growth factor A + H2O Homo sapiens activation, the substrate is localized specifically to the apical surface of the luminal and glandular epithelium of uterine endometrium in the receptive phase, but barely detectable in the non-receptive phase mature platelet-derived growth factor A + ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q92824
-
-

Source Tissue

Source Tissue Comment Organism Textmining
uterine endometrium the enzyme is up-regulated in the human endometrium specifically at the time of epithelial receptivity Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
proform platelet-derived growth factor A + H2O activation Homo sapiens mature platelet-derived growth factor A + ?
-
 ?
proform platelet-derived growth factor A + H2O activation, the substrate is localized specifically to the apical surface of the luminal and glandular epithelium of uterine endometrium in the receptive phase, but barely detectable in the non-receptive phase Homo sapiens mature platelet-derived growth factor A + ?
-
 ?

Synonyms

Synonyms Comment Organism
PC6
-
 Homo sapiens
proprotein convertase 5/6
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens the enzyme is up-regulated in the human endometrium specifically at the time of epithelial receptivity up

General Information

General Information Comment Organism
evolution the enzyme is a serine protease of the proprotein convertase family Homo sapiens
physiological function proprotein convertase 5/6 cleaves and activates platelet-derived growth factor A in the human endometrium in preparation for embryo implantation, overview. The enzyme plays an important role in converting precursor proteins into their active forms through specific proteolysis Homo sapiens