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Literature summary for 3.4.21.B26 extracted from
- Time for endothelial cell proprotein convertase PC5/6 in cardiovascular medicine? (2011), J. Mol. Med., 89, 1061-1063.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| antitrypsin-Portland | alpha1-antitrypsin-PDX | Mus musculus | |
| decanonyl-RVKR-chloromethylketone | - |
Mus musculus |  |
| hexa-D-arginine | - |
Mus musculus | |
| nona-D-arginine | - |
Mus musculus | |
| transforming growth factor beta-binding protein-2 | - |
Mus musculus | |
| transforming growth factor beta-binding protein-3 | - |
Mus musculus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | the membrane-bound isoform is mostly expressed in intestine and kidney | Mus musculus | 16020 | - |
| soluble | major isoform | Mus musculus | - |
- |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| adrenal cortex | - |
Mus musculus | - |
| aorta | - |
Mus musculus | - |
| colon | - |
Mus musculus | - |
| embryo | - |
Mus musculus | - |
| endothelial cell | - |
Mus musculus | - |
| kidney | - |
Mus musculus | - |
| small intestine | - |
Mus musculus | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PC5/6 | - |
Mus musculus |
| PCSK5 | - |
Mus musculus |
| proprotein convertase PC5/6 | - |
Mus musculus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | complete knockout of PC5/6 is lethal between E4.5-7.5 | Mus musculus |
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