Literature summary for 3.4.21.B26 extracted from

Stawowy, P.; Kallisch, H.; Veinot, J.P.; Kilimnik, A.; Prichett, W.; Goetze, S.; Seidah, N.G.; Chretien, M.; Fleck, E.; Graf, K.
Endoproteolytic activation of av integrin by proprotein convertase PC5 is required for Vascular smooth muscle cell adhesion to vitronectin and integrin-dependent signaling (2004), Circulation, 109, 770-776.

Search for more literature for 3.4.21.B26

Application

Application	Comment	Organism
medicine	av endoproteolytic activation is necessary for integrin-mediated adhesion and migration as well as signaling and requires PC5 in vascular smooth muscle cells	Rattus norvegicus
medicine	carotid atherosclerotic lesions obtained by endaterectomy contain PC5, PC5 colocalizes with av integrin	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
decanoyl-Arg-Val-Lys-Arg-chloromethylketone	0.05 mM inhibits PC activity and consequently av cleavage	Rattus norvegicus
additional information	av cleavage not inhibited by the MMP-inhibitor GM6001 and PC5-specific antisense oligonucleotide-3	Rattus norvegicus
PC5-specific antisense oligonucleotide-1	inhibits PC activity and consequently av cleavage	Rattus norvegicus
PC5-specific antisense oligonucleotide-2	inhibits PC activity and consequently av cleavage, most potent inhibitor	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q92824	-	-
Rattus norvegicus	P41413	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
additional information	carotid plaque	Homo sapiens	-
myofibroblast	-	Homo sapiens	-
vascular smooth muscle cell	-	Rattus norvegicus	-

Synonyms

Synonyms	Comment	Organism
PC5	-	Homo sapiens
PC5	-	Rattus norvegicus

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Release 2023.1 (January 2023)