Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | - |
Homo sapiens | 5737 | - |
nucleus | - |
Homo sapiens | 5634 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
plasma hepatocyte growth factor activator zymogen + H2O | Homo sapiens | activation, hepatocyte growth factor is mainly secreted from fibroblasts as an inactive single-chain precursor, which lacks biological activity | mature HGF activator + ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9YSK2 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
prostate cancer cell | expression of human kallikrein 1-related peptidase 4 in prostate cancer patients with bone metastasis or advanced stage, immunohistochemic analysis of 62 prostate cancer samples | Homo sapiens | - |
prostate gland | very low enzyme levels in healthy tissue | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
plasma hepatocyte growth factor activator zymogen + H2O | activation, hepatocyte growth factor is mainly secreted from fibroblasts as an inactive single-chain precursor, which lacks biological activity | Homo sapiens | mature HGF activator + ? | - |
? | |
plasma hepatocyte growth factor activator zymogen + H2O | conversion to an active two-chain form | Homo sapiens | mature HGF activator + ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
kallikrein 1-related peptidase 4 | - |
Homo sapiens |
KLK4 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | the enzyme activates the hepatocyte growth factor, a multifunctional growth factor that plays an important role in cancer progression via its specific receptor tyrosine kinase MET, a c-met proto-oncogene product. Correlation between phospho-MET, MET, KLK4 expression and clinicopathological parameters, overview | Homo sapiens |