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Literature summary for 3.4.21.B12 extracted from

  • Wang, W.; Mize, G.J.; Zhang, X.; Takayama, T.K.
    Kallikrein-related peptidase-4 initiates tumor-stroma interactions in prostate cancer through protease-activated receptor-1 (2010), Int. J. Cancer, 126, 599-610.
    View publication on PubMed
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
protease-activated receptor-1 + H2O Homo sapiens KLK4 cleaves protease-activated receptor-1 at the activation site on intact cell surface ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
LNCaP cell
-
 Homo sapiens
-
prostate cancer cell KLK4 is produced exclusively by the epithelial cancer cells Homo sapiens
-
prostate gland
-
 Homo sapiens
-
WPMY-1 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
protease-activated receptor-1 + H2O KLK4 cleaves protease-activated receptor-1 at the activation site on intact cell surface Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
kallikrein-related peptidase-4
-
 Homo sapiens
KLK4
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function kallikrein-related peptidase-4 (KLK4) initiates tumor-stroma interactions in prostate cancer through protease-activated receptor-1 (PAR-1). KLK4 triggers transmembrane signaling and upregulates interleukin-6 in WPMY-1 cells through PAR-1. Cancer epithelium produces KLK4 to activate PAR-1 in the surrounding stroma, which in-turn releases cytokines (interleukin-6) that stimulate cancer cells to proliferate and increase production of kallikreins Homo sapiens