Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.21.B12 extracted from

  • Lu, Y.; Papagerakis, P.; Yamakoshi, Y.; Hu, J.C.; Bartlett, J.D.; Simmer, J.P.
    Functions of KLK4 and MMP-20 in dental enamel formation (2008), Biol. Chem., 389, 695-700.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.B12

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9Y5K2
-
-

Source Tissue

Source Tissue Comment Organism Textmining
tooth two proteases are secreted into the enamel matrix of developing teeth. The early protease is enamelysin (MMP-20). The late protease is kallikrein 4. Kallikrein 4 is secreted by transition and maturation stage ameloblasts Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information two proteases are secreted into the enamel matrix of developing teeth. The early protease is enamelysin (MMP-20). The late protease is kallikrein 4. KLK4 aggressively degrades the retained organic matrix following the termination of enamel protein secretion. The principle functions of MMP-20 and KLK4 in dental enamel formation are to facilitate the orderly replacement of organic matrix with mineral, generating an enamel layer that is harder, less porous, and unstained by retained enamel proteins Homo sapiens ?
-
 ?