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Literature summary for 3.4.21.B12 extracted from

  • Debela, M.; Beaufort, N.; Magdolen, V.; Schechter, N.M.; Craik, C.S.; Schmitt, M.; Bode, W.; Goettig, P.
    Structures and specificity of the human kallikrein-related peptidases KLK 4, 5, 6, and 7 (2008), Biol. Chem., 389, 623-632.
    View publication on PubMed
Search for more literature for 3.4.21.B12

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9Y5K2
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein one glycosylation site Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information preference for Arg over Lys at position P1. KLK4 prefers as P2 residue the medium-sized polar Gln over the more hydrophobic Val, Leu, Thr, and Pro, whereas large aromatic and basic side chains are not accepted. Marked specificity for medium-sized to large hydrophobic P4 residues. Activation cleavage site: SCSQ-IING Homo sapiens ?
-
 ?
proform of KLK3 + H2O Ile-Leu-Ser-Arg-/-Ile-Val activation site Homo sapiens ?
-
 ?
urokinase-type plasminogen activator + H2O cleaves after Pro-Arg-Phe-Lys Homo sapiens ?
-
 ?
urokinase-type plasminogen activator receptor + H2O cleaves after Thr-Tyr-Ser-Arg as well as in the sequence Val-Gln-Tyr-Arg-/-Ser-Gly Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
EM serine proteinase 1
-
 Homo sapiens
kallikrein-like protein 1
-
 Homo sapiens
KLK4
-
 Homo sapiens
serine protease 17
-
 Homo sapiens