Literature summary for 3.4.21.B12 extracted from

Wright, J.T.; Daly, B.; Simmons, D.; Hong, S.; Hart, S.P.; Hart, T.C.; Atsawasuwan, P.; Yamauchi, M.
Human enamel phenotype associated with amelogenesis imperfecta and a kallikrein-4 (g.2142G>A) proteinase mutation (2006), Eur. J. Oral Sci., 114 Suppl 1; 13-7, discussion 39-41, 379.

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Application

Application	Comment	Organism
medicine	KLK-4 proteinase is essential for the final crystallite growth of enamel but is not critical for crystallite orientation, prism formation or enamel thickness	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
additional information	KLK-4 mutant (g.2142G>A), enamel is of normal thickness but opaque throughout its width compared with normal enamel. Enamel has a normal prismatic structure and generally a well-organized and discernable crystallite composition. In some areas, globular structures are present where crystallites are not discernable or appear to have an altered morphology. The KLK-4 mutant enamel has an increased protein content compared with normal enamel	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
enamel	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
kallikrein-4 proteinase	-	Homo sapiens
KLK-4 proteinase	-	Homo sapiens

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Release 2023.1 (January 2023)