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Literature summary for 3.4.21.B12 extracted from
- The new human tissue kallikrein gene family: structure, function, and association to disease (2001), Endocr. Rev., 22, 184-204.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| androgens | up-regulation of gene expression | Homo sapiens | |
| progestins | up-regulation of gene expression in breast carcinoma | Homo sapiens |  |
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | enzyme might be useful as diagnostic marker in ovarian cancer | Homo sapiens |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | enzyme is regulated by steroid hormones, contains androgen response elements in the proximal promotor region | ? | - |
? | |
| polypeptide + H2O | Homo sapiens | - |
peptides | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q9Y5K2 | - |
- |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| proteolysis of polypeptides | substrate binding pocket contains an Asp residue | Homo sapiens | |
| proteolysis of polypeptides | enzyme is a serine protease | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| BT-474 cell | breast carcinoma cell line, enzyme is upregulated by progetsins and androgens | Homo sapiens | - |
| cell culture | breast carcinoma cell line | Homo sapiens | - |
| LNCaP cell | prostate carcinoma cell line, enzyme is upregulated by androgens | Homo sapiens | - |
| ovarian carcinoma cell | gene overexpression | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | enzyme is regulated by steroid hormones, contains androgen response elements in the proximal promotor region | Homo sapiens | ? | - |
? | |
| polypeptide + H2O | - |
Homo sapiens | peptides | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| EMSP1 | - |
Homo sapiens |
| K4 | - |
Homo sapiens |
| PRSS17 | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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