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Literature summary for 3.4.21.98 extracted from

  • Steinkuhler, C.; Biasiol, G.; Brunetti, M.; Urbani, A.; Koch, U.; Cortese, R.; Pessi, A.; de Francesco, R.
    Product inhibition of the hepatitis C virus NS3 protease (1998), Biochemistry, 37, 8899-8905.
    View publication on PubMed
Search for more literature for 3.4.21.98

Protein Variants

Protein Variants Comment Organism
K136M slightly higher Km and lower kcat than wild-type Hepacivirus C
K136R slightly higher Km and slightly lower kcat than wild-type Hepacivirus C
R155S higher Km and lower kcat than wild-type Hepacivirus C

Inhibitors

Inhibitors Comment Organism Structure
DCSTPC-OH
-
 Hepacivirus C
DEMEEC-NH2
-
 Hepacivirus C
DEMEEC-OH
-
 Hepacivirus C
EDVVAbuC-OH
-
 Hepacivirus C

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.8
-
 EDVVAbuCSMSY-NH2
-
 Hepacivirus C
10
-
 DEMEECASHLPYK
-
 Hepacivirus C

Organism

Organism UniProt Comment Textmining
Hepacivirus C
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Hepacivirus C

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
DCSTPCSGSW-NH2 + H2O
-
 Hepacivirus C DCSTPC + SGSW-NH2
-
 ?
DEMEECASHLPYK + H2O
-
 Hepacivirus C DEMEEC + ASHLPYK
-
 ?
EDVV-4-aminobutyric acid-CSMSY-NH2 + H2O
-
 Hepacivirus C EDVV-4-aminobutyric acid-C + SMSY-NH2
-
 ?
EDVVAbuCSMSY-NH2 + H2O
-
 Hepacivirus C ?
-
 ?