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Literature summary for 3.4.21.98 extracted from

  • Bianchi, E.; Orru, S.; Dal Piaz F.; Ingenito, R.; Casbarra, A.; Biasiol, G.; Koch, U.; Pucci, P.; Pessi, A.
    Conformational changes in human hepatitis C virus NS3 protease upon binding of product-based inhibitors (1999), Biochemistry, 38, 13844-13852.
    View publication on PubMed
Search for more literature for 3.4.21.98

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli Hepacivirus C

Inhibitors

Inhibitors Comment Organism Structure
acetyl-Asp-Glu-3,3-diphenylalanine-Glu-beta-cyclohexylalanine-Cys-OH 0.00005 mM, 50% inhibition Hepacivirus C
acetyl-Asp-Glu-Leu-Glu-beta-cyclohexylalanine-Cys-OH 0.0026 mM, 50% inhibition Hepacivirus C
acetyl-Asp-Glu-Leu-Ile-beta-cyclohexylalanine-Cys-OH 0.00006 mM, 50% inhibition Hepacivirus C
acetyl-Asp-Glu-Met-Glu-beta-cyclohexylalanine-Cys-OH 0.00035 mM, 50% inhibition Hepacivirus C
acetyl-Asp-Glu-Met-Glu-Glu-Cys-OH 0.001 mM, 50% inhibition Hepacivirus C
acetyl-Glu-Leu-Glu-beta-cyclohexylalanine-Cys-OH 5 mM, 50% inhibition Hepacivirus C
N-acetyl-L-alpha-aspartyl-L-alpha-glutamyl-beta-phenyl-L-phenylalanyl-L-alpha-glutamyl-3-cyclohexyl-L-alanine 1.17 mM, 50% inhibition Hepacivirus C

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
19540
-
 truncated form of the protease, lacking the N-terminal Met-Ala, mass spectrometry Hepacivirus C

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
hepatitis virus C polyprotein + H2O Hepacivirus C maturation of the viral polyprotein ?
-
 ?

Organism

Organism UniProt Comment Textmining
Hepacivirus C
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Hepacivirus C

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
hepatitis virus C polyprotein + H2O maturation of the viral polyprotein Hepacivirus C ?
-
 ?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00005
-
 acetyl-Asp-Glu-3,3-diphenylalanine-Glu-beta-cyclohexylalanine-Cys-OH
-
 Hepacivirus C
0.00006
-
 acetyl-Asp-Glu-Leu-Ile-beta-cyclohexylalanine-Cys-OH
-
 Hepacivirus C
0.00035
-
 acetyl-Asp-Glu-Met-Glu-beta-cyclohexylalanine-Cys-OH
-
 Hepacivirus C
0.001
-
 acetyl-Asp-Glu-Met-Glu-Glu-Cys-OH
-
 Hepacivirus C
0.0026
-
 acetyl-Asp-Glu-Leu-Glu-beta-cyclohexylalanine-Cys-OH
-
 Hepacivirus C
1.17
-
 N-acetyl-L-alpha-aspartyl-L-alpha-glutamyl-beta-phenyl-L-phenylalanyl-L-alpha-glutamyl-3-cyclohexyl-L-alanine
-
 Hepacivirus C
5
-
 acetyl-Glu-Leu-Glu-beta-cyclohexylalanine-Cys-OH
-
 Hepacivirus C