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Literature summary for 3.4.21.98 extracted from

  • Cicero, D.O.; Barbato, G.; Koch, U.; Ingallinella, P.; Bianchi, E.; Nardi, M.C.; Steinkuhler, C.; Cortese, R.; Matassa, V.; de Francesco, R.; Pessi, A.; Bazzo, R.
    Structural characterization of the interactions of optimized product inhibitors with the N-terminal proteinase domain of the hepatitis C virus (HCV) NS3 protein by NMR and modelling studies (1999), J. Mol. Biol., 289, 385-396.
    View publication on PubMed
Search for more literature for 3.4.21.98

Activating Compound

Activating Compound Comment Organism Structure
NS4A enhances the activity of NS3 protease in all cleavages via the formation of an NS3/NS4A Hepacivirus C

Inhibitors

Inhibitors Comment Organism Structure
acetyl-3,3-diphenylalanine-beta-cyclohexylalanine-Cys-OH 0.3 mM, 50% inhibition Hepacivirus C
acetyl-Asp-Glu-3,3-diphenylalanine-Glu-beta-cyclohexylalanine-Cys-OH 0.00005 mM, 50% inhibition Hepacivirus C
acetyl-Asp-Glu-3,3-diphenylalanine-Ile-beta-cyclohexylalanine-OH 0.046 mM, 50% inhibition Hepacivirus C
acetyl-Glu-3,3-diphenylalanine-Glu-beta-cyclohexyalanine-Cys-OH 0.0014 mM, 50% inhibition Hepacivirus C
acetyl-Glu-beta-cyclohexylalanine-Cys-OH 0.46 mM, 50% inhibition Hepacivirus C

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
hepatitis virus C polyprotein + H2O Hepacivirus C maturation of the viral polyprotein ?
-
 ?

Organism

Organism UniProt Comment Textmining
Hepacivirus C
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
hepatitis virus C polyprotein + H2O maturation of the viral polyprotein Hepacivirus C ?
-
 ?
precursor polyprotein of hepatitis C virus + H2O
-
 Hepacivirus C ?
-
 ?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00005
-
 acetyl-Asp-Glu-3,3-diphenylalanine-Glu-beta-cyclohexylalanine-Cys-OH
-
 Hepacivirus C
0.0014
-
 acetyl-Glu-3,3-diphenylalanine-Glu-beta-cyclohexyalanine-Cys-OH
-
 Hepacivirus C
0.046
-
 acetyl-Asp-Glu-3,3-diphenylalanine-Ile-beta-cyclohexylalanine-OH
-
 Hepacivirus C
0.3
-
 acetyl-3,3-diphenylalanine-beta-cyclohexylalanine-Cys-OH
-
 Hepacivirus C
0.46
-
 acetyl-Glu-beta-cyclohexylalanine-Cys-OH
-
 Hepacivirus C