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Literature summary for 3.4.21.98 extracted from

  • Wang, A.X.; Chen, J.; Zhao, Q.; Sun, L.Q.; Friborg, J.; Yu, F.; Hernandez, D.; Good, A.C.; Klei, H.E.; Rajamani, R.; Mosure, K.; Knipe, J.O.; Li, D.; Zhu, J.; Levesque, P.C.; McPhee, F.; Meanwell, N.A.; Scola, P.M.
    Structure-activity relationships of 4-hydroxy-4-biaryl-proline acylsulfonamide tripeptides A series of potent NS3 protease inhibitors for the treatment of hepatitis C virus (2017), Bioorg. Med. Chem. Lett., 27, 590-596 .
    View publication on PubMed
Search for more literature for 3.4.21.98

Inhibitors

Inhibitors Comment Organism Structure
asunaprevir
-
 hepatitis C virus genotype 1a
asunaprevir
-
 Hepatitis C virus genotype 1b
BMS-605339
-
 hepatitis C virus genotype 1a
BMS-605339
-
 Hepatitis C virus genotype 1b
additional information design and synthesis of a series of potent NS3 protease inhibitors for the treatment of hepatitis C virus, structure-activity relationships of 4-hydroxy-4-biaryl-proline acylsulfonamide tripeptides, overview hepatitis C virus genotype 1a
additional information design and synthesis of a series of potent NS3 protease inhibitors for the treatment of hepatitis C virus, structure-activity relationships of 4-hydroxy-4-biaryl-proline acylsulfonamide tripeptides, overview Hepatitis C virus genotype 1b
N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-4-(3-chlorophenyl)-N-[(1R,2S)-1-[(cyclopropanesulfonyl)acetyl]-2-ethenylcyclopropyl]-4-hydroxy-L-prolinamide
-
 hepatitis C virus genotype 1a
N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-4-(3-chlorophenyl)-N-[(1R,2S)-1-[(cyclopropanesulfonyl)acetyl]-2-ethenylcyclopropyl]-4-hydroxy-L-prolinamide
-
 Hepatitis C virus genotype 1b
N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-4-biphenyl-4-yl-N-[(1R,2S)-1-[(cyclopropylsulfonyl)acetyl]-2-ethenylcyclopropyl]-4-hydroxy-L-prolinamide
-
 hepatitis C virus genotype 1a
N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-4-biphenyl-4-yl-N-[(1R,2S)-1-[(cyclopropylsulfonyl)acetyl]-2-ethenylcyclopropyl]-4-hydroxy-L-prolinamide
-
 Hepatitis C virus genotype 1b
N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-4-biphenyl-4-yl-N-[(1R,2S)-1-[(cyclopropylsulfonyl)acetyl]-2-ethenylcyclopropyl]-4-methoxy-L-prolinamide
-
 hepatitis C virus genotype 1a
N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-4-biphenyl-4-yl-N-[(1R,2S)-1-[(cyclopropylsulfonyl)acetyl]-2-ethenylcyclopropyl]-4-methoxy-L-prolinamide
-
 Hepatitis C virus genotype 1b
N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-N-[(1R)-2-carboxy-2-ethenylcyclopropyl]-4-[(7-methoxy-2-phenylquinolin-4-yl)oxy]-L-prolinamide
-
 hepatitis C virus genotype 1a
N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-N-[(1R)-2-carboxy-2-ethenylcyclopropyl]-4-[(7-methoxy-2-phenylquinolin-4-yl)oxy]-L-prolinamide
-
 Hepatitis C virus genotype 1b
N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-N-[(1R)-2-[(cyclopropylsulfonyl)carbamoyl]-2-ethenylcyclopropyl]-4-[(6-methoxyisoquinolin-1-yl)oxy]-L-prolinamide
-
 hepatitis C virus genotype 1a
N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-N-[(1R)-2-[(cyclopropylsulfonyl)carbamoyl]-2-ethenylcyclopropyl]-4-[(6-methoxyisoquinolin-1-yl)oxy]-L-prolinamide
-
 Hepatitis C virus genotype 1b
N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-N-[(1R,2S)-1-[(cyclopropanesulfonyl)acetyl]-2-ethenylcyclopropyl]-4-(3-fluorophenyl)-4-hydroxy-L-prolinamide
-
 hepatitis C virus genotype 1a
N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-N-[(1R,2S)-1-[(cyclopropanesulfonyl)acetyl]-2-ethenylcyclopropyl]-4-(3-fluorophenyl)-4-hydroxy-L-prolinamide
-
 Hepatitis C virus genotype 1b
N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-N-[(1R,2S)-1-[(cyclopropanesulfonyl)acetyl]-2-ethenylcyclopropyl]-4-(4-fluorophenyl)-4-hydroxy-L-prolinamide
-
 hepatitis C virus genotype 1a
N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-N-[(1R,2S)-1-[(cyclopropanesulfonyl)acetyl]-2-ethenylcyclopropyl]-4-(4-fluorophenyl)-4-hydroxy-L-prolinamide
-
 Hepatitis C virus genotype 1b
N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-N-[(1R,2S)-1-[(cyclopropanesulfonyl)acetyl]-2-ethenylcyclopropyl]-4-hydroxy-4-(3-methoxyphenyl)-L-prolinamide
-
 hepatitis C virus genotype 1a
N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-N-[(1R,2S)-1-[(cyclopropanesulfonyl)acetyl]-2-ethenylcyclopropyl]-4-hydroxy-4-(3-methoxyphenyl)-L-prolinamide
-
 Hepatitis C virus genotype 1b
N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-N-[(1R,2S)-1-[(cyclopropanesulfonyl)acetyl]-2-ethenylcyclopropyl]-4-hydroxy-4-(3-methylphenyl)-L-prolinamide
-
 hepatitis C virus genotype 1a
N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-N-[(1R,2S)-1-[(cyclopropanesulfonyl)acetyl]-2-ethenylcyclopropyl]-4-hydroxy-4-(3-methylphenyl)-L-prolinamide
-
 Hepatitis C virus genotype 1b
N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-N-[(1R,2S)-1-[(cyclopropanesulfonyl)acetyl]-2-ethenylcyclopropyl]-4-hydroxy-4-(4-methoxyphenyl)-L-prolinamide
-
 hepatitis C virus genotype 1a
N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-N-[(1R,2S)-1-[(cyclopropanesulfonyl)acetyl]-2-ethenylcyclopropyl]-4-hydroxy-4-(4-methoxyphenyl)-L-prolinamide
-
 Hepatitis C virus genotype 1b
N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-N-[(1R,2S)-1-[(cyclopropanesulfonyl)acetyl]-2-ethenylcyclopropyl]-4-hydroxy-4-phenyl-L-prolinamide
-
 hepatitis C virus genotype 1a
N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-N-[(1R,2S)-1-[(cyclopropanesulfonyl)acetyl]-2-ethenylcyclopropyl]-4-hydroxy-4-phenyl-L-prolinamide
-
 Hepatitis C virus genotype 1b
N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-N-[(1R,2S)-1-[(cyclopropylsulfonyl)acetyl]-2-ethenylcyclopropyl]-4-(2,5-dimethylphenyl)-4-hydroxy-L-prolinamide
-
 hepatitis C virus genotype 1a
N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-N-[(1R,2S)-1-[(cyclopropylsulfonyl)acetyl]-2-ethenylcyclopropyl]-4-(2,5-dimethylphenyl)-4-hydroxy-L-prolinamide
-
 Hepatitis C virus genotype 1b
N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-N-[(1R,2S)-1-[(cyclopropylsulfonyl)acetyl]-2-ethenylcyclopropyl]-4-(3,5-dimethylphenyl)-4-hydroxy-L-prolinamide
-
 hepatitis C virus genotype 1a
N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-N-[(1R,2S)-1-[(cyclopropylsulfonyl)acetyl]-2-ethenylcyclopropyl]-4-(3,5-dimethylphenyl)-4-hydroxy-L-prolinamide
-
 Hepatitis C virus genotype 1b
N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-N-[(1R,2S)-1-[(cyclopropylsulfonyl)acetyl]-2-ethenylcyclopropyl]-4-(3-fluoro-4-methylphenyl)-4-hydroxy-L-prolinamide
-
 hepatitis C virus genotype 1a
N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-N-[(1R,2S)-1-[(cyclopropylsulfonyl)acetyl]-2-ethenylcyclopropyl]-4-(3-fluoro-4-methylphenyl)-4-hydroxy-L-prolinamide
-
 Hepatitis C virus genotype 1b
N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-N-[(1R,2S)-1-[(cyclopropylsulfonyl)acetyl]-2-ethenylcyclopropyl]-4-(4-fluoro-3-methylphenyl)-4-hydroxy-L-prolinamide
-
 hepatitis C virus genotype 1a
N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-N-[(1R,2S)-1-[(cyclopropylsulfonyl)acetyl]-2-ethenylcyclopropyl]-4-(4-fluoro-3-methylphenyl)-4-hydroxy-L-prolinamide
-
 Hepatitis C virus genotype 1b
N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-N-[(1R,2S)-1-[(cyclopropylsulfonyl)acetyl]-2-ethenylcyclopropyl]-4-(5-fluoro-2-methoxyphenyl)-4-hydroxy-L-prolinamide
-
 hepatitis C virus genotype 1a
N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-N-[(1R,2S)-1-[(cyclopropylsulfonyl)acetyl]-2-ethenylcyclopropyl]-4-(5-fluoro-2-methoxyphenyl)-4-hydroxy-L-prolinamide
-
 Hepatitis C virus genotype 1b
N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-N-[(1R,2S)-1-[(cyclopropylsulfonyl)acetyl]-2-ethenylcyclopropyl]-4-hydroxy-4-(2'-methoxybiphenyl-4-yl)-L-prolinamide
-
 hepatitis C virus genotype 1a
N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-N-[(1R,2S)-1-[(cyclopropylsulfonyl)acetyl]-2-ethenylcyclopropyl]-4-hydroxy-4-(2'-methoxybiphenyl-4-yl)-L-prolinamide
-
 Hepatitis C virus genotype 1b
N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-N-[(1R,2S)-1-[(cyclopropylsulfonyl)acetyl]-2-ethenylcyclopropyl]-4-hydroxy-4-(4'-methoxybiphenyl-3-yl)-L-prolinamide
-
 hepatitis C virus genotype 1a
N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-N-[(1R,2S)-1-[(cyclopropylsulfonyl)acetyl]-2-ethenylcyclopropyl]-4-hydroxy-4-(4'-methoxybiphenyl-3-yl)-L-prolinamide
-
 Hepatitis C virus genotype 1b
N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-N-[(1R,2S)-1-[(cyclopropylsulfonyl)acetyl]-2-ethenylcyclopropyl]-4-hydroxy-4-(4-phenoxyphenyl)-L-prolinamide
-
 hepatitis C virus genotype 1a
N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-N-[(1R,2S)-1-[(cyclopropylsulfonyl)acetyl]-2-ethenylcyclopropyl]-4-hydroxy-4-(4-phenoxyphenyl)-L-prolinamide
-
 Hepatitis C virus genotype 1b
N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-N-[(1R,2S)-1-[(cyclopropylsulfonyl)acetyl]-2-ethenylcyclopropyl]-4-hydroxy-4-naphthalen-2-yl-L-prolinamide
-
 hepatitis C virus genotype 1a
N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-N-[(1R,2S)-1-[(cyclopropylsulfonyl)acetyl]-2-ethenylcyclopropyl]-4-hydroxy-4-naphthalen-2-yl-L-prolinamide
-
 Hepatitis C virus genotype 1b
N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-N-[(1R,2S)-1-[(cyclopropylsulfonyl)acetyl]-2-ethenylcyclopropyl]-4-hydroxy-4-[2-(morpholin-4-ylmethyl)phenyl]-L-prolinamide
-
 hepatitis C virus genotype 1a
N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-N-[(1R,2S)-1-[(cyclopropylsulfonyl)acetyl]-2-ethenylcyclopropyl]-4-hydroxy-4-[2-(morpholin-4-ylmethyl)phenyl]-L-prolinamide
-
 Hepatitis C virus genotype 1b
N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-N-[(1R,2S)-1-[(cyclopropylsulfonyl)acetyl]-2-ethenylcyclopropyl]-4-hydroxy-4-[3-(morpholin-4-ylmethyl)phenyl]-L-prolinamide
-
 hepatitis C virus genotype 1a
N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-N-[(1R,2S)-1-[(cyclopropylsulfonyl)acetyl]-2-ethenylcyclopropyl]-4-hydroxy-4-[3-(morpholin-4-ylmethyl)phenyl]-L-prolinamide
-
 Hepatitis C virus genotype 1b
N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-N-[(1R,2S)-1-[(cyclopropylsulfonyl)acetyl]-2-ethenylcyclopropyl]-4-hydroxy-4-[3-(propan-2-yl)phenyl]-L-prolinamide
-
 hepatitis C virus genotype 1a
N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-N-[(1R,2S)-1-[(cyclopropylsulfonyl)acetyl]-2-ethenylcyclopropyl]-4-hydroxy-4-[3-(propan-2-yl)phenyl]-L-prolinamide
-
 Hepatitis C virus genotype 1b
N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-N-[(1R,2S)-1-[(cyclopropylsulfonyl)acetyl]-2-ethenylcyclopropyl]-4-hydroxy-4-[3-(propan-2-yloxy)phenyl]-L-prolinamide
-
 hepatitis C virus genotype 1a
N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-N-[(1R,2S)-1-[(cyclopropylsulfonyl)acetyl]-2-ethenylcyclopropyl]-4-hydroxy-4-[3-(propan-2-yloxy)phenyl]-L-prolinamide
-
 Hepatitis C virus genotype 1b
N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-N-[(1R,2S)-1-[(cyclopropylsulfonyl)acetyl]-2-ethenylcyclopropyl]-4-hydroxy-4-[4-(1,3-thiazol-2-yl)phenyl]-L-prolinamide
-
 hepatitis C virus genotype 1a
N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-N-[(1R,2S)-1-[(cyclopropylsulfonyl)acetyl]-2-ethenylcyclopropyl]-4-hydroxy-4-[4-(1,3-thiazol-2-yl)phenyl]-L-prolinamide
-
 Hepatitis C virus genotype 1b
N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-N-[(1R,2S)-1-[(cyclopropylsulfonyl)acetyl]-2-ethenylcyclopropyl]-4-hydroxy-4-[4-(1H-pyrrol-1-yl)phenyl]-L-prolinamide
-
 hepatitis C virus genotype 1a
N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-N-[(1R,2S)-1-[(cyclopropylsulfonyl)acetyl]-2-ethenylcyclopropyl]-4-hydroxy-4-[4-(1H-pyrrol-1-yl)phenyl]-L-prolinamide
-
 Hepatitis C virus genotype 1b
N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-N-[(1R,2S)-1-[(cyclopropylsulfonyl)acetyl]-2-ethenylcyclopropyl]-4-hydroxy-4-[4-(pyridin-2-yl)phenyl]-L-prolinamide
-
 hepatitis C virus genotype 1a
N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-N-[(1R,2S)-1-[(cyclopropylsulfonyl)acetyl]-2-ethenylcyclopropyl]-4-hydroxy-4-[4-(pyridin-2-yl)phenyl]-L-prolinamide
-
 Hepatitis C virus genotype 1b
N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-N-[(1R,2S)-1-[(cyclopropylsulfonyl)acetyl]-2-ethenylcyclopropyl]-4-[3-(dimethylamino)phenyl]-4-hydroxy-L-prolinamide
-
 hepatitis C virus genotype 1a
N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-N-[(1R,2S)-1-[(cyclopropylsulfonyl)acetyl]-2-ethenylcyclopropyl]-4-[3-(dimethylamino)phenyl]-4-hydroxy-L-prolinamide
-
 Hepatitis C virus genotype 1b
N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4S)-4-(1,3-benzothiazol-2-yl)-N-[(1R,2S)-1-[(cyclopropylsulfonyl)acetyl]-2-ethenylcyclopropyl]-4-hydroxy-L-prolinamide
-
 hepatitis C virus genotype 1a
N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4S)-4-(1,3-benzothiazol-2-yl)-N-[(1R,2S)-1-[(cyclopropylsulfonyl)acetyl]-2-ethenylcyclopropyl]-4-hydroxy-L-prolinamide
-
 Hepatitis C virus genotype 1b
N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4S)-N-[(1R,2S)-1-[(cyclopropylsulfonyl)acetyl]-2-ethenylcyclopropyl]-4-hydroxy-4-prop-2-en-1-yl-L-prolinamide
-
 hepatitis C virus genotype 1a
N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4S)-N-[(1R,2S)-1-[(cyclopropylsulfonyl)acetyl]-2-ethenylcyclopropyl]-4-hydroxy-4-prop-2-en-1-yl-L-prolinamide
-
 Hepatitis C virus genotype 1b
N-(tert-butoxycarbonyl)-3-methyl-L-valyl-N-[(1R,2S)-1-[(cyclopropylsulfonyl)acetyl]-2-ethenylcyclopropyl]-4-oxo-L-prolinamide
-
 hepatitis C virus genotype 1a
N-(tert-butoxycarbonyl)-3-methyl-L-valyl-N-[(1R,2S)-1-[(cyclopropylsulfonyl)acetyl]-2-ethenylcyclopropyl]-4-oxo-L-prolinamide
-
 Hepatitis C virus genotype 1b

Organism

Organism UniProt Comment Textmining
hepatitis C virus genotype 1a P27958 HCV, isolate H
-
Hepatitis C virus genotype 1b P26663 HCV, isolate BK
-

Synonyms

Synonyms Comment Organism
NS3/4A protease complex
-
 hepatitis C virus genotype 1a
NS3/4A protease complex
-
 Hepatitis C virus genotype 1b

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000001
-
 pH and temperature not specified in the publication hepatitis C virus genotype 1a BMS-605339
0.000002
-
 pH and temperature not specified in the publication hepatitis C virus genotype 1a N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-4-biphenyl-4-yl-N-[(1R,2S)-1-[(cyclopropylsulfonyl)acetyl]-2-ethenylcyclopropyl]-4-methoxy-L-prolinamide
0.000002
-
 pH and temperature not specified in the publication hepatitis C virus genotype 1a N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-N-[(1R,2S)-1-[(cyclopropylsulfonyl)acetyl]-2-ethenylcyclopropyl]-4-hydroxy-4-[4-(1,3-thiazol-2-yl)phenyl]-L-prolinamide
0.000002
-
 pH and temperature not specified in the publication hepatitis C virus genotype 1a N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-N-[(1R,2S)-1-[(cyclopropylsulfonyl)acetyl]-2-ethenylcyclopropyl]-4-hydroxy-4-[4-(pyridin-2-yl)phenyl]-L-prolinamide
0.000004
-
 pH and temperature not specified in the publication hepatitis C virus genotype 1a N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-4-biphenyl-4-yl-N-[(1R,2S)-1-[(cyclopropylsulfonyl)acetyl]-2-ethenylcyclopropyl]-4-hydroxy-L-prolinamide
0.000005
-
 pH and temperature not specified in the publication hepatitis C virus genotype 1a N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-N-[(1R,2S)-1-[(cyclopropylsulfonyl)acetyl]-2-ethenylcyclopropyl]-4-hydroxy-4-(2'-methoxybiphenyl-4-yl)-L-prolinamide
0.000007
-
 pH and temperature not specified in the publication hepatitis C virus genotype 1a N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-N-[(1R,2S)-1-[(cyclopropylsulfonyl)acetyl]-2-ethenylcyclopropyl]-4-hydroxy-4-[4-(1H-pyrrol-1-yl)phenyl]-L-prolinamide
0.000009
-
 pH and temperature not specified in the publication Hepatitis C virus genotype 1b N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-4-biphenyl-4-yl-N-[(1R,2S)-1-[(cyclopropylsulfonyl)acetyl]-2-ethenylcyclopropyl]-4-methoxy-L-prolinamide
0.000012
-
 pH and temperature not specified in the publication Hepatitis C virus genotype 1b BMS-605339
0.000024
-
 pH and temperature not specified in the publication Hepatitis C virus genotype 1b N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-N-[(1R,2S)-1-[(cyclopropylsulfonyl)acetyl]-2-ethenylcyclopropyl]-4-hydroxy-4-(2'-methoxybiphenyl-4-yl)-L-prolinamide
0.000026
-
 pH and temperature not specified in the publication Hepatitis C virus genotype 1b N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-4-biphenyl-4-yl-N-[(1R,2S)-1-[(cyclopropylsulfonyl)acetyl]-2-ethenylcyclopropyl]-4-hydroxy-L-prolinamide
0.000026
-
 pH and temperature not specified in the publication hepatitis C virus genotype 1a N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-N-[(1R,2S)-1-[(cyclopropylsulfonyl)acetyl]-2-ethenylcyclopropyl]-4-hydroxy-4-naphthalen-2-yl-L-prolinamide
0.000039
-
 pH and temperature not specified in the publication Hepatitis C virus genotype 1b N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-N-[(1R,2S)-1-[(cyclopropylsulfonyl)acetyl]-2-ethenylcyclopropyl]-4-hydroxy-4-[4-(pyridin-2-yl)phenyl]-L-prolinamide
0.000041
-
 pH and temperature not specified in the publication Hepatitis C virus genotype 1b N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-N-[(1R,2S)-1-[(cyclopropylsulfonyl)acetyl]-2-ethenylcyclopropyl]-4-hydroxy-4-[4-(1,3-thiazol-2-yl)phenyl]-L-prolinamide
0.00005
-
 pH and temperature not specified in the publication hepatitis C virus genotype 1a N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-N-[(1R,2S)-1-[(cyclopropylsulfonyl)acetyl]-2-ethenylcyclopropyl]-4-hydroxy-4-(4-phenoxyphenyl)-L-prolinamide
0.000052
-
 pH and temperature not specified in the publication hepatitis C virus genotype 1a N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-N-[(1R,2S)-1-[(cyclopropanesulfonyl)acetyl]-2-ethenylcyclopropyl]-4-hydroxy-4-(3-methoxyphenyl)-L-prolinamide
0.000057
-
 pH and temperature not specified in the publication hepatitis C virus genotype 1a N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-N-[(1R,2S)-1-[(cyclopropanesulfonyl)acetyl]-2-ethenylcyclopropyl]-4-(3-fluorophenyl)-4-hydroxy-L-prolinamide
0.000076
-
 pH and temperature not specified in the publication hepatitis C virus genotype 1a N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-N-[(1R,2S)-1-[(cyclopropanesulfonyl)acetyl]-2-ethenylcyclopropyl]-4-hydroxy-4-(3-methylphenyl)-L-prolinamide
0.00008
-
 pH and temperature not specified in the publication hepatitis C virus genotype 1a N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-4-(3-chlorophenyl)-N-[(1R,2S)-1-[(cyclopropanesulfonyl)acetyl]-2-ethenylcyclopropyl]-4-hydroxy-L-prolinamide
0.00008
-
 pH and temperature not specified in the publication hepatitis C virus genotype 1a N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-N-[(1R,2S)-1-[(cyclopropylsulfonyl)acetyl]-2-ethenylcyclopropyl]-4-(3,5-dimethylphenyl)-4-hydroxy-L-prolinamide
0.000097
-
 pH and temperature not specified in the publication Hepatitis C virus genotype 1b N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-N-[(1R,2S)-1-[(cyclopropylsulfonyl)acetyl]-2-ethenylcyclopropyl]-4-hydroxy-4-[4-(1H-pyrrol-1-yl)phenyl]-L-prolinamide
0.000101
-
 pH and temperature not specified in the publication hepatitis C virus genotype 1a N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-N-[(1R,2S)-1-[(cyclopropylsulfonyl)acetyl]-2-ethenylcyclopropyl]-4-hydroxy-4-[3-(propan-2-yloxy)phenyl]-L-prolinamide
0.000105
-
 pH and temperature not specified in the publication hepatitis C virus genotype 1a N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-N-[(1R,2S)-1-[(cyclopropanesulfonyl)acetyl]-2-ethenylcyclopropyl]-4-hydroxy-4-(4-methoxyphenyl)-L-prolinamide
0.000127
-
 pH and temperature not specified in the publication hepatitis C virus genotype 1a N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4S)-4-(1,3-benzothiazol-2-yl)-N-[(1R,2S)-1-[(cyclopropylsulfonyl)acetyl]-2-ethenylcyclopropyl]-4-hydroxy-L-prolinamide
0.000134
-
 pH and temperature not specified in the publication hepatitis C virus genotype 1a N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-N-[(1R,2S)-1-[(cyclopropylsulfonyl)acetyl]-2-ethenylcyclopropyl]-4-(4-fluoro-3-methylphenyl)-4-hydroxy-L-prolinamide
0.000136
-
 pH and temperature not specified in the publication hepatitis C virus genotype 1a N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-N-[(1R,2S)-1-[(cyclopropylsulfonyl)acetyl]-2-ethenylcyclopropyl]-4-(2,5-dimethylphenyl)-4-hydroxy-L-prolinamide
0.00014
-
 pH and temperature not specified in the publication hepatitis C virus genotype 1a N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-N-[(1R,2S)-1-[(cyclopropanesulfonyl)acetyl]-2-ethenylcyclopropyl]-4-hydroxy-4-phenyl-L-prolinamide
0.000162
-
 pH and temperature not specified in the publication hepatitis C virus genotype 1a N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-N-[(1R,2S)-1-[(cyclopropylsulfonyl)acetyl]-2-ethenylcyclopropyl]-4-hydroxy-4-[3-(morpholin-4-ylmethyl)phenyl]-L-prolinamide
0.00019
-
 pH and temperature not specified in the publication hepatitis C virus genotype 1a N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-N-[(1R,2S)-1-[(cyclopropanesulfonyl)acetyl]-2-ethenylcyclopropyl]-4-(4-fluorophenyl)-4-hydroxy-L-prolinamide
0.000265
-
 pH and temperature not specified in the publication Hepatitis C virus genotype 1b N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-N-[(1R,2S)-1-[(cyclopropylsulfonyl)acetyl]-2-ethenylcyclopropyl]-4-hydroxy-4-(4-phenoxyphenyl)-L-prolinamide
0.000291
-
 pH and temperature not specified in the publication hepatitis C virus genotype 1a N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-N-[(1R,2S)-1-[(cyclopropylsulfonyl)acetyl]-2-ethenylcyclopropyl]-4-hydroxy-4-[2-(morpholin-4-ylmethyl)phenyl]-L-prolinamide
0.000412
-
 pH and temperature not specified in the publication Hepatitis C virus genotype 1b N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-N-[(1R,2S)-1-[(cyclopropylsulfonyl)acetyl]-2-ethenylcyclopropyl]-4-hydroxy-4-naphthalen-2-yl-L-prolinamide
0.000568
-
 pH and temperature not specified in the publication hepatitis C virus genotype 1a N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-N-[(1R,2S)-1-[(cyclopropylsulfonyl)acetyl]-2-ethenylcyclopropyl]-4-(3-fluoro-4-methylphenyl)-4-hydroxy-L-prolinamide
0.00062
-
 pH and temperature not specified in the publication hepatitis C virus genotype 1a N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-N-[(1R,2S)-1-[(cyclopropylsulfonyl)acetyl]-2-ethenylcyclopropyl]-4-hydroxy-4-(4'-methoxybiphenyl-3-yl)-L-prolinamide
0.000703
-
 pH and temperature not specified in the publication hepatitis C virus genotype 1a N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-N-[(1R,2S)-1-[(cyclopropylsulfonyl)acetyl]-2-ethenylcyclopropyl]-4-hydroxy-4-[3-(propan-2-yl)phenyl]-L-prolinamide
0.000728
-
 pH and temperature not specified in the publication hepatitis C virus genotype 1a N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-N-[(1R,2S)-1-[(cyclopropylsulfonyl)acetyl]-2-ethenylcyclopropyl]-4-(5-fluoro-2-methoxyphenyl)-4-hydroxy-L-prolinamide
0.00096
-
 pH and temperature not specified in the publication hepatitis C virus genotype 1a N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-N-[(1R,2S)-1-[(cyclopropylsulfonyl)acetyl]-2-ethenylcyclopropyl]-4-[3-(dimethylamino)phenyl]-4-hydroxy-L-prolinamide
0.00112
-
 pH and temperature not specified in the publication Hepatitis C virus genotype 1b N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4S)-4-(1,3-benzothiazol-2-yl)-N-[(1R,2S)-1-[(cyclopropylsulfonyl)acetyl]-2-ethenylcyclopropyl]-4-hydroxy-L-prolinamide
0.00147
-
 pH and temperature not specified in the publication Hepatitis C virus genotype 1b N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-N-[(1R,2S)-1-[(cyclopropanesulfonyl)acetyl]-2-ethenylcyclopropyl]-4-hydroxy-4-(4-methoxyphenyl)-L-prolinamide
0.0015
-
 pH and temperature not specified in the publication hepatitis C virus genotype 1a N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4S)-N-[(1R,2S)-1-[(cyclopropylsulfonyl)acetyl]-2-ethenylcyclopropyl]-4-hydroxy-4-prop-2-en-1-yl-L-prolinamide
0.00231
-
 pH and temperature not specified in the publication Hepatitis C virus genotype 1b N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-N-[(1R,2S)-1-[(cyclopropylsulfonyl)acetyl]-2-ethenylcyclopropyl]-4-(2,5-dimethylphenyl)-4-hydroxy-L-prolinamide
0.00236
-
 pH and temperature not specified in the publication Hepatitis C virus genotype 1b N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-N-[(1R,2S)-1-[(cyclopropanesulfonyl)acetyl]-2-ethenylcyclopropyl]-4-hydroxy-4-phenyl-L-prolinamide
0.00247
-
 pH and temperature not specified in the publication Hepatitis C virus genotype 1b N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-N-[(1R,2S)-1-[(cyclopropanesulfonyl)acetyl]-2-ethenylcyclopropyl]-4-(4-fluorophenyl)-4-hydroxy-L-prolinamide
0.00321
-
 pH and temperature not specified in the publication Hepatitis C virus genotype 1b N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-N-[(1R,2S)-1-[(cyclopropylsulfonyl)acetyl]-2-ethenylcyclopropyl]-4-hydroxy-4-(4'-methoxybiphenyl-3-yl)-L-prolinamide
0.00327
-
 pH and temperature not specified in the publication Hepatitis C virus genotype 1b N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-N-[(1R,2S)-1-[(cyclopropanesulfonyl)acetyl]-2-ethenylcyclopropyl]-4-hydroxy-4-(3-methylphenyl)-L-prolinamide
0.0034
-
 pH and temperature not specified in the publication Hepatitis C virus genotype 1b N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-N-[(1R,2S)-1-[(cyclopropylsulfonyl)acetyl]-2-ethenylcyclopropyl]-4-[3-(dimethylamino)phenyl]-4-hydroxy-L-prolinamide
0.00346
-
 pH and temperature not specified in the publication Hepatitis C virus genotype 1b N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-N-[(1R,2S)-1-[(cyclopropylsulfonyl)acetyl]-2-ethenylcyclopropyl]-4-hydroxy-4-[3-(morpholin-4-ylmethyl)phenyl]-L-prolinamide
0.00366
-
 pH and temperature not specified in the publication Hepatitis C virus genotype 1b N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-4-(3-chlorophenyl)-N-[(1R,2S)-1-[(cyclopropanesulfonyl)acetyl]-2-ethenylcyclopropyl]-4-hydroxy-L-prolinamide
0.0037
-
 pH and temperature not specified in the publication Hepatitis C virus genotype 1b N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-N-[(1R,2S)-1-[(cyclopropanesulfonyl)acetyl]-2-ethenylcyclopropyl]-4-hydroxy-4-(3-methoxyphenyl)-L-prolinamide
0.0039
-
 pH and temperature not specified in the publication hepatitis C virus genotype 1a N-(tert-butoxycarbonyl)-3-methyl-L-valyl-N-[(1R,2S)-1-[(cyclopropylsulfonyl)acetyl]-2-ethenylcyclopropyl]-4-oxo-L-prolinamide
0.00394
-
 pH and temperature not specified in the publication Hepatitis C virus genotype 1b N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-N-[(1R,2S)-1-[(cyclopropylsulfonyl)acetyl]-2-ethenylcyclopropyl]-4-(5-fluoro-2-methoxyphenyl)-4-hydroxy-L-prolinamide
0.00406
-
 pH and temperature not specified in the publication Hepatitis C virus genotype 1b N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-N-[(1R,2S)-1-[(cyclopropanesulfonyl)acetyl]-2-ethenylcyclopropyl]-4-(3-fluorophenyl)-4-hydroxy-L-prolinamide
0.00424
-
 pH and temperature not specified in the publication Hepatitis C virus genotype 1b N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-N-[(1R,2S)-1-[(cyclopropylsulfonyl)acetyl]-2-ethenylcyclopropyl]-4-(3-fluoro-4-methylphenyl)-4-hydroxy-L-prolinamide
0.00495
-
 pH and temperature not specified in the publication Hepatitis C virus genotype 1b N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-N-[(1R,2S)-1-[(cyclopropylsulfonyl)acetyl]-2-ethenylcyclopropyl]-4-hydroxy-4-[2-(morpholin-4-ylmethyl)phenyl]-L-prolinamide
0.00625
-
 pH and temperature not specified in the publication Hepatitis C virus genotype 1b N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-N-[(1R,2S)-1-[(cyclopropylsulfonyl)acetyl]-2-ethenylcyclopropyl]-4-hydroxy-4-[3-(propan-2-yloxy)phenyl]-L-prolinamide
0.00645
-
 pH and temperature not specified in the publication Hepatitis C virus genotype 1b N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-N-[(1R,2S)-1-[(cyclopropylsulfonyl)acetyl]-2-ethenylcyclopropyl]-4-(3,5-dimethylphenyl)-4-hydroxy-L-prolinamide
0.0077
-
 pH and temperature not specified in the publication Hepatitis C virus genotype 1b N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-N-[(1R,2S)-1-[(cyclopropylsulfonyl)acetyl]-2-ethenylcyclopropyl]-4-(4-fluoro-3-methylphenyl)-4-hydroxy-L-prolinamide
0.00837
-
 pH and temperature not specified in the publication Hepatitis C virus genotype 1b N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-N-[(1R,2S)-1-[(cyclopropylsulfonyl)acetyl]-2-ethenylcyclopropyl]-4-hydroxy-4-[3-(propan-2-yl)phenyl]-L-prolinamide
0.0305
-
 pH and temperature not specified in the publication Hepatitis C virus genotype 1b N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4S)-N-[(1R,2S)-1-[(cyclopropylsulfonyl)acetyl]-2-ethenylcyclopropyl]-4-hydroxy-4-prop-2-en-1-yl-L-prolinamide
0.0707
-
 pH and temperature not specified in the publication Hepatitis C virus genotype 1b N-(tert-butoxycarbonyl)-3-methyl-L-valyl-N-[(1R,2S)-1-[(cyclopropylsulfonyl)acetyl]-2-ethenylcyclopropyl]-4-oxo-L-prolinamide