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Literature summary for 3.4.21.98 extracted from

  • Jensen, S.B.; Serre, S.B.; Humes, D.G.; Ramirez, S.; Li, Y.P.; Bukh, J.; Gottwein, J.M.
    Substitutions at NS3 residue 155, 156, or 168 of hepatitis C virus genotypes 2 to 6 induce complex patterns of protease inhibitor resistance (2015), Antimicrob. Agents Chemother., 59, 7426-7436 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
genotyping, expression of wild-type and mutant variant viruses in Huh7.5 cells hepatitis C virus genotype 1a
genotyping, expression of wild-type and mutant variant viruses in Huh7.5 cells Hepatitis C virus genotype 2a
genotyping, expression of wild-type and mutant variant viruses in Huh7.5 cells Hepatitis C virus genotype 4a
genotyping, expression of wild-type and mutant variant viruses in Huh7.5 cells Hepatitis C virus genotype 5a
genotyping, expression of wild-type and mutant variant viruses in Huh7.5 cells Hepatitis C virus subtype 3a

Protein Variants

Protein Variants Comment Organism
A156G virus mutant variant hepatitis C virus genotype 1a
A156G virus mutant variant Hepatitis C virus genotype 2a
A156G virus mutant variant Hepatitis C virus genotype 4a
A156G virus mutant variant Hepatitis C virus genotype 5a
A156G virus mutant variant Hepatitis C virus subtype 3a
A156S virus mutant variant hepatitis C virus genotype 1a
A156S virus mutant variant Hepatitis C virus genotype 2a
A156S virus mutant variant Hepatitis C virus genotype 4a
A156S virus mutant variant Hepatitis C virus genotype 5a
A156S virus mutant variant Hepatitis C virus subtype 3a
A156T virus mutant variant hepatitis C virus genotype 1a
A156T virus mutant variant Hepatitis C virus genotype 2a
A156T virus mutant variant Hepatitis C virus genotype 4a
A156T virus mutant variant Hepatitis C virus genotype 5a
A156T virus mutant variant Hepatitis C virus subtype 3a
A156V virus mutant variant hepatitis C virus genotype 1a
A156V virus mutant variant Hepatitis C virus genotype 2a
A156V virus mutant variant Hepatitis C virus genotype 4a
A156V virus mutant variant Hepatitis C virus genotype 5a
A156V virus mutant variant Hepatitis C virus subtype 3a
D168A virus mutant variant hepatitis C virus genotype 1a
D168A virus mutant variant Hepatitis C virus genotype 2a
D168A virus mutant variant Hepatitis C virus genotype 4a
D168A virus mutant variant Hepatitis C virus genotype 5a
D168E virus mutant variant hepatitis C virus genotype 1a
D168E virus mutant variant Hepatitis C virus genotype 2a
D168E virus mutant variant Hepatitis C virus genotype 4a
D168E virus mutant variant Hepatitis C virus genotype 5a
D168G virus mutant variant hepatitis C virus genotype 1a
D168G virus mutant variant Hepatitis C virus genotype 2a
D168G virus mutant variant Hepatitis C virus genotype 4a
D168G virus mutant variant Hepatitis C virus genotype 5a
D168H virus mutant variant hepatitis C virus genotype 1a
D168H virus mutant variant Hepatitis C virus genotype 2a
D168H virus mutant variant Hepatitis C virus genotype 4a
D168H virus mutant variant Hepatitis C virus genotype 5a
D168N virus mutant variant hepatitis C virus genotype 1a
D168N virus mutant variant Hepatitis C virus genotype 2a
D168N virus mutant variant Hepatitis C virus genotype 4a
D168N virus mutant variant Hepatitis C virus genotype 5a
D168V virus mutant variant hepatitis C virus genotype 1a
D168V virus mutant variant Hepatitis C virus genotype 2a
D168V virus mutant variant Hepatitis C virus genotype 4a
D168V virus mutant variant Hepatitis C virus genotype 5a
additional information for hepatitis C virus (HCV) genotype 1, substitutions at NS3 protease positions 155, 156, and 168 are the main determinants of PI resistance. For other genotypes, similar substitutions are selected during protease inhibitor treatment but are not characterized systematically. Most mutant variants show decreased fitness compared to that of the original viruses. Fitness characteristics of HCV genotype 1 to 6 recombinants with substitutions at NS3P positions 155, 156, or 168, overview hepatitis C virus genotype 1a
additional information for hepatitis C virus (HCV) genotype 1, substitutions at NS3 protease positions 155, 156, and 168 are the main determinants of PI resistance. For other genotypes, similar substitutions are selected during protease inhibitor treatment but are not characterized systematically. Most mutant variants show decreased fitness compared to that of the original viruses. Fitness characteristics of HCV genotype 1 to 6 recombinants with substitutions at NS3P positions 155, 156, or 168, overview Hepatitis C virus genotype 2a
additional information for hepatitis C virus (HCV) genotype 1, substitutions at NS3 protease positions 155, 156, and 168 are the main determinants of PI resistance. For other genotypes, similar substitutions are selected during protease inhibitor treatment but are not characterized systematically. Most mutant variants show decreased fitness compared to that of the original viruses. Fitness characteristics of HCV genotype 1 to 6 recombinants with substitutions at NS3P positions 155, 156, or 168, overview Hepatitis C virus genotype 4a
additional information for hepatitis C virus (HCV) genotype 1, substitutions at NS3 protease positions 155, 156, and 168 are the main determinants of PI resistance. For other genotypes, similar substitutions are selected during protease inhibitor treatment but are not characterized systematically. Most mutant variants show decreased fitness compared to that of the original viruses. Fitness characteristics of HCV genotype 1 to 6 recombinants with substitutions at NS3P positions 155, 156, or 168, overview Hepatitis C virus genotype 5a
additional information for hepatitis C virus (HCV) genotype 1, substitutions at NS3 protease positions 155, 156, and 168 are the main determinants of PI resistance. For other genotypes, similar substitutions are selected during protease inhibitor treatment but are not characterized systematically. Most mutant variants show decreased fitness compared to that of the original viruses. Fitness characteristics of HCV genotype 1 to 6 recombinants with substitutions at NS3P positions 155, 156, or 168, overview Hepatitis C virus subtype 3a
Q168A virus mutant variant Hepatitis C virus subtype 3a
Q168E virus mutant variant Hepatitis C virus subtype 3a
Q168G virus mutant variant Hepatitis C virus subtype 3a
Q168H virus mutant variant Hepatitis C virus subtype 3a
Q168N virus mutant variant Hepatitis C virus subtype 3a
Q168V virus mutant variant Hepatitis C virus subtype 3a
R155A virus mutant variant hepatitis C virus genotype 1a
R155A virus mutant variant Hepatitis C virus genotype 2a
R155A virus mutant variant Hepatitis C virus genotype 4a
R155A virus mutant variant Hepatitis C virus genotype 5a
R155A virus mutant variant Hepatitis C virus subtype 3a
R155E virus mutant variant hepatitis C virus genotype 1a
R155E virus mutant variant Hepatitis C virus genotype 2a
R155E virus mutant variant Hepatitis C virus genotype 4a
R155E virus mutant variant Hepatitis C virus genotype 5a
R155E virus mutant variant Hepatitis C virus subtype 3a
R155G virus mutant variant hepatitis C virus genotype 1a
R155G virus mutant variant Hepatitis C virus genotype 2a
R155G virus mutant variant Hepatitis C virus genotype 4a
R155G virus mutant variant Hepatitis C virus genotype 5a
R155G virus mutant variant Hepatitis C virus subtype 3a
R155H virus mutant variant hepatitis C virus genotype 1a
R155H virus mutant variant Hepatitis C virus genotype 2a
R155H virus mutant variant Hepatitis C virus genotype 4a
R155H virus mutant variant Hepatitis C virus genotype 5a
R155H virus mutant variant Hepatitis C virus subtype 3a
R155K virus mutant variant hepatitis C virus genotype 1a
R155K virus mutant variant Hepatitis C virus genotype 2a
R155K virus mutant variant Hepatitis C virus genotype 4a
R155K virus mutant variant Hepatitis C virus genotype 5a
R155K virus mutant variant Hepatitis C virus subtype 3a
R155Q virus mutant variant hepatitis C virus genotype 1a
R155Q virus mutant variant Hepatitis C virus genotype 2a
R155Q virus mutant variant Hepatitis C virus genotype 4a
R155Q virus mutant variant Hepatitis C virus genotype 5a
R155Q virus mutant variant Hepatitis C virus subtype 3a
R155T virus mutant variant hepatitis C virus genotype 1a
R155T virus mutant variant Hepatitis C virus genotype 2a
R155T virus mutant variant Hepatitis C virus genotype 4a
R155T virus mutant variant Hepatitis C virus genotype 5a
R155T virus mutant variant Hepatitis C virus subtype 3a

Inhibitors

Inhibitors Comment Organism Structure
asunaprevir
-
hepatitis C virus genotype 1a
asunaprevir
-
Hepatitis C virus genotype 2a
asunaprevir
-
Hepatitis C virus genotype 4a
asunaprevir
-
Hepatitis C virus genotype 5a
asunaprevir
-
Hepatitis C virus subtype 3a
boceprevir
-
hepatitis C virus genotype 1a
boceprevir
-
Hepatitis C virus genotype 2a
boceprevir
-
Hepatitis C virus genotype 4a
boceprevir
-
Hepatitis C virus genotype 5a
boceprevir
-
Hepatitis C virus subtype 3a
deldeprevir
-
hepatitis C virus genotype 1a
deldeprevir
-
Hepatitis C virus genotype 2a
deldeprevir
-
Hepatitis C virus genotype 4a
deldeprevir
-
Hepatitis C virus genotype 5a
deldeprevir
-
Hepatitis C virus subtype 3a
faldaprevir
-
hepatitis C virus genotype 1a
faldaprevir
-
Hepatitis C virus genotype 2a
faldaprevir
-
Hepatitis C virus genotype 4a
faldaprevir
-
Hepatitis C virus genotype 5a
faldaprevir
-
Hepatitis C virus subtype 3a
grazoprevir
-
hepatitis C virus genotype 1a
grazoprevir
-
Hepatitis C virus genotype 2a
grazoprevir
-
Hepatitis C virus genotype 4a
grazoprevir
-
Hepatitis C virus genotype 5a
grazoprevir
-
Hepatitis C virus subtype 3a
additional information susceptibility/efficiency and resistance, respectively, of virus genotypes and variants with respect to antiviral agents, EC50 values, detailed overview hepatitis C virus genotype 1a
additional information susceptibility/efficiency and resistance, respectively, of virus genotypes and variants with respect to antiviral agents, EC50 values, detailed overview Hepatitis C virus genotype 2a
additional information susceptibility/efficiency and resistance, respectively, of virus genotypes and variants with respect to antiviral agents, EC50 values, detailed overview Hepatitis C virus genotype 4a
additional information susceptibility/efficiency and resistance, respectively, of virus genotypes and variants with respect to antiviral agents, EC50 values, detailed overview Hepatitis C virus genotype 5a
additional information susceptibility/efficiency and resistance, respectively, of virus genotypes and variants with respect to antiviral agents, EC50 values, detailed overview Hepatitis C virus subtype 3a
paritaprevir
-
hepatitis C virus genotype 1a
paritaprevir
-
Hepatitis C virus genotype 2a
paritaprevir
-
Hepatitis C virus genotype 4a
paritaprevir
-
Hepatitis C virus genotype 5a
paritaprevir
-
Hepatitis C virus subtype 3a
simeprevir
-
hepatitis C virus genotype 1a
simeprevir
-
Hepatitis C virus genotype 2a
simeprevir
-
Hepatitis C virus genotype 4a
simeprevir
-
Hepatitis C virus genotype 5a
simeprevir
-
Hepatitis C virus subtype 3a
telaprevir
-
hepatitis C virus genotype 1a
telaprevir
-
Hepatitis C virus genotype 2a
telaprevir
-
Hepatitis C virus genotype 4a
telaprevir
-
Hepatitis C virus genotype 5a
telaprevir
-
Hepatitis C virus subtype 3a
vaniprevir
-
hepatitis C virus genotype 1a
vaniprevir
-
Hepatitis C virus genotype 2a
vaniprevir
-
Hepatitis C virus genotype 4a
vaniprevir
-
Hepatitis C virus genotype 5a
vaniprevir
-
Hepatitis C virus subtype 3a

Organism

Organism UniProt Comment Textmining
hepatitis C virus genotype 1a
-
HCV, isolate HK6a
-
hepatitis C virus genotype 1a
-
HCV, isolate TN
-
Hepatitis C virus genotype 2a Q99IB8 HCV, isolate JFH-1
-
Hepatitis C virus genotype 4a O39929 HCV, isolate ED43
-
Hepatitis C virus genotype 5a O91936 HCV, isolate SA13
-
Hepatitis C virus subtype 3a
-
HCV, isolates S52 and 452
-

Synonyms

Synonyms Comment Organism
NS3 protease
-
hepatitis C virus genotype 1a
NS3 protease
-
Hepatitis C virus genotype 2a
NS3 protease
-
Hepatitis C virus genotype 4a
NS3 protease
-
Hepatitis C virus genotype 5a
NS3 protease
-
Hepatitis C virus subtype 3a