Literature summary for 3.4.21.98 extracted from

Liu, Y.H.; Ramanathan, L.; Malcolm, B.; Njoroge, G.; Chan, T.Y.; Pramanik, B.N.
Screening and rank ordering of reversible mechanism-based inhibitors of hepatitis C virus NS3 protease using electrospray ionization mass spectrometry (2011), J. Mass Spectrom., 46, 764-771.

Search for more literature for 3.4.21.98

Activating Compound

Activating Compound	Comment	Organism	Structure
4A cofactor peptide	-	Hepacivirus C

Protein Variants

Protein Variants	Comment	Organism
S139A	active site mutant	Hepacivirus C

Inhibitors

Inhibitors	Comment	Organism	Structure
4MeBu-P-norvaline-(CO)-GMSYS-NH2	CVS4440	Hepacivirus C
acetyl-EEVVP-norvaline-(CO)-GMSYS-NH2	CVS4437	Hepacivirus C
acetyl-EEVVP-norvaline-(CO)-phenethylamide	CVS4442	Hepacivirus C
acetyl-P-norvaline-(CO)-GMSYS-NH2	CVS4441	Hepacivirus C
acetyl-VVP-norvaline-(CO)-G-NH2	SCH212986	Hepacivirus C
acetyl-VVP-norvaline-(CO)-S(Bzl)-NH2	SCH215426	Hepacivirus C
SCH217135	-	Hepacivirus C
SCH217142	-	Hepacivirus C
SCH217942	-	Hepacivirus C

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
21080	-	mass spectroscopy	Hepacivirus C

Organism

Organism	UniProt	Comment	Textmining
Hepacivirus C	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
acetyl-DTEDVVCCSMSYTWTGK + H2O	-	Hepacivirus C	?	-	?

Synonyms

Synonyms	Comment	Organism
NS3 protease	-	Hepacivirus C

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
30	-	assay at	Hepacivirus C

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
6.5	-	assay at	Hepacivirus C

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.000096	-	acetyl-EEVVP-norvaline-(CO)-GMSYS-NH2	pH 6.5, 30°C	Hepacivirus C
0.0016	-	acetyl-EEVVP-norvaline-(CO)-phenethylamide	pH 6.5, 30°C	Hepacivirus C
0.02	-	SCH217135	pH 6.5, 30°C	Hepacivirus C
0.048	-	SCH217142	pH 6.5, 30°C	Hepacivirus C
0.06	-	4MeBu-P-norvaline-(CO)-GMSYS-NH2	pH 6.5, 30°C	Hepacivirus C
0.06	-	SCH217942	pH 6.5, 30°C	Hepacivirus C
0.08	-	acetyl-P-norvaline-(CO)-GMSYS-NH2	pH 6.5, 30°C	Hepacivirus C

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Release 2023.1 (January 2023)