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Literature summary for 3.4.21.98 extracted from

  • Li, X.D.; Sun, L.; Seth, R.B.; Pineda, G.; Chen, Z.J.
    Hepatitis C virus protease NS3/4A cleaves mitochondrial antiviral signaling protein off the mitochondria to evade innate immunity (2005), Proc. Natl. Acad. Sci. USA, 102, 17717-17722.
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
medicine natural substrate of enzyme is the mitochondrial antiviral signaling protein. Blocking the cleavage of mitochondrial antiviral signaling protein as means for prevention and treatment of hepatitis C Hepacivirus C

Localization

Localization Comment Organism GeneOntology No. Textmining
additional information colocalization with mitochondrial antiviral signaling protein in mitochondrial membrane of host Hepacivirus C
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
mitochondrial antiviral signaling protein + H2O Hepacivirus C i.e. MAVS, cleavage at Cys-508 ?
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 ?

Organism

Organism UniProt Comment Textmining
Hepacivirus C
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
mitochondrial antiviral signaling protein + H2O i.e. MAVS, cleavage at Cys-508 Hepacivirus C ?
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 ?