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Literature summary for 3.4.21.98 extracted from

  • Goudreau, N.; Brochu, C.; Cameron, D.R.; Duceppe, J.S.; Faucher, A.M.; Ferland, J.M.; Grand-Maitre, C.; Poirier, M.; Simoneau, B.; Tsantrizos, Y.S.
    Potent inhibitors of the hepatitis C virus NS3 protease: design and synthesis of macrocyclic substrate-based beta-strand mimics (2004), J. Org. Chem., 69, 6185-6201.
    View publication on PubMed
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Inhibitors

Inhibitors Comment Organism Structure
(1R)-1-([(4R)-1-[(2S)-2-[(tert-butoxycarbonyl)amino]heptanoyl]-4-[(7-methoxy-2-phenylquinolin-4-yl)oxy]-L-prolyl]amino)-2-ethenylcyclopropanecarboxylic acid 50% inhibition at 0.0000004 mM, NMR and molecular dynamics analysis Hepacivirus C
(2R,6S,10E,14aR,16aS)-6-[(tert-butoxycarbonyl)amino]-2-[(7-methoxy-2-phenylquinolin-4-yl)oxy]-5,16-dioxo-1,2,3,6,7,8,9,12,13,13a,14,15,16,16a-tetradecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-14a(5H)-carboxylic acid 50% inhibition at 0.000077 mM, NMR and molecular dynamics analysis Hepacivirus C
(2R,6S,12Z,14aR,16aS)-6-[(tert-butoxycarbonyl)amino]-2-[(7-methoxy-2-phenylquinolin-4-yl)oxy]-5,16-dioxo-1,2,3,6,7,8,9,10,11,13a,14,15,16,16a-tetradecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-14a(5H)-carboxylic acid 50% inhibition at 0.000011 mM, NMR and molecular dynamics analysis Hepacivirus C
(2R,6S,14aR,16aS)-6-[(tert-butoxycarbonyl)amino]-2-[(7-methoxy-2-phenylquinolin-4-yl)oxy]-5,16-dioxohexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-14a(5H)-carboxylic acid 50% inhibition at 0.000027 mM, NMR and molecular dynamics analysis Hepacivirus C

Organism

Organism UniProt Comment Textmining
Hepacivirus C
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