Protein Variants | Comment | Organism |
---|---|---|
D168Q | mutation in strain 1a, mutation has no impact on inhibition profile | Hepacivirus C |
Q168D | mutation in strain 3a, mutation has no impact on inhibition profile | Hepacivirus C |
R123T | mutation in strain 1a, inhibition profile is identical to that of enzyme from 3a strain | Hepacivirus C |
R123T/D168Q | mutation in strain 1a, inhibition profile is identical to that of enzyme from 3a strain | Hepacivirus C |
T123R | mutation in strain 3a, inhibition profile is identical to that of enzyme from 1a strain | Hepacivirus C |
T123R/Q168D | mutation in strain 3a, inhibition profile is identical to that of enzyme from 1a strain | Hepacivirus C |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
acetyl-Asp-(D-Glu)-(allyloxycarbonyl-L-lysine)-(L-cyclohexylalanine)-Cys-OH | - |
Hepacivirus C | |
acetyl-Asp-(D-Glu)-Leu-Ile-L-cyclohexylalanine-Cys-OH | - |
Hepacivirus C | |
acetyl-Asp-(D-Glu)-Tyr-Ile-L-cyclohexylalanine-Cys-OH | - |
Hepacivirus C | |
acetyl-Asp-(D-glutamine)-Leu-Ile-L-cyclohexylalanine-Cys-OH | - |
Hepacivirus C | |
acetyl-Asp-(D-homoglutamate)-Leu-Ile-L-cyclohexylalanine-Cys-OH | - |
Hepacivirus C | |
acetyl-Asp-(D-homoleucine)-Leu-Ile-(L-cyclohexylalanine)-Cys-OH | - |
Hepacivirus C | |
acetyl-DEMEEC-OH | - |
Hepacivirus C | |
acetyl-DYPSPC-OH | - |
Hepacivirus C | |
acetyl-ECTTPC-OH | - |
Hepacivirus C | |
acetyl-EDVVCC-OH | - |
Hepacivirus C | |
acetyl-QSVVCC-OH | - |
Hepacivirus C |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Hepacivirus C | - |
genotype 1a, 1b, and 3a | - |
Purification (Comment) | Organism |
---|---|
- |
Hepacivirus C |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-DTEDVVP-norvaline-O-4-phenylazophenol + H2O | - |
Hepacivirus C | ? | - |
? | |
viral polyprotein + H2O | - |
Hepacivirus C | ? | - |
? |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0011 | - |
acetyl-Asp-(D-homoglutamate)-Leu-Ile-L-cyclohexylalanine-Cys-OH | pH 6.5, 30°C, strain 1b | Hepacivirus C | |
0.0012 | - |
acetyl-Asp-(D-homoglutamate)-Leu-Ile-L-cyclohexylalanine-Cys | pH 6.5, 30°C, strain 1a | Hepacivirus C | |
0.0018 | - |
acetyl-Asp-(D-Glu)-Tyr-Ile-L-cyclohexylalanine-Cys-OH | pH 6.5, 30°C, strain 1a | Hepacivirus C | |
0.0022 | - |
acetyl-Asp-(D-homoglutamate)-Leu-Ile-L-cyclohexylalanine-Cys-OH | pH 6.5, 30°C, strain 1a, mutant enzyme D168Q | Hepacivirus C | |
0.0026 | - |
acetyl-Asp-(D-homoglutamate)-Leu-Ile-L-cyclohexylalanine-Cys-OH | pH 6.5, 30°C, strain 3a, mutant enzyme T123R/Q168D | Hepacivirus C | |
0.0027 | - |
acetyl-Asp-(D-Glu)-Tyr-Ile-L-cyclohexylalanine-Cys-OH | pH 6.5, 30°C, strain 1b | Hepacivirus C | |
0.0028 | - |
acetyl-Asp-(D-Glu)-Leu-Ile-L-cyclohexylalanine-Cys-OH | pH 6.5, 30°C, strain 3a, mutant enzyme T123R/Q168D | Hepacivirus C | |
0.0029 | - |
acetyl-Asp-(D-Glu)-Tyr-Ile-L-cyclohexylalanine-Cys-OH | pH 6.5, 30°C, strain 3a, mutant enzyme T123R | Hepacivirus C | |
0.0032 | - |
acetyl-Asp-(D-Glu)-Leu-Ile-L-cyclohexylalanine-Cys-OH | pH 6.5, 30°C, strain 3a, mutant enzyme T123R | Hepacivirus C | |
0.0032 | - |
acetyl-Asp-(D-homoglutamate)-Leu-Ile-L-cyclohexylalanine-Cys-OH | pH 6.5, 30°C, strain 3a, mutant enzyme T123R | Hepacivirus C | |
0.0033 | - |
acetyl-Asp-(D-Glu)-Tyr-Ile-L-cyclohexylalanine-Cys-OH | pH 6.5, 30°C, strain 1a, mutant enzyme D168Q | Hepacivirus C | |
0.004 | - |
acetyl-Asp-(D-Glu)-Tyr-Ile-L-cyclohexylalanine-Cys-OH | pH 6.5, 30°C, strain 3a, mutant enzyme T123R/Q168D | Hepacivirus C | |
0.0045 | - |
acetyl-Asp-(D-Glu)-Leu-Ile-L-cyclohexylalanine-Cys-OH | pH 6.5, 30°C, strain 1a | Hepacivirus C | |
0.005 | - |
acetyl-Asp-(D-Glu)-Leu-Ile-L-cyclohexylalanine-Cys-OH | pH 6.5, 30°C, strain 1a, mutant enzyme D168Q | Hepacivirus C | |
0.0052 | - |
acetyl-Asp-(D-Glu)-Leu-Ile-L-cyclohexylalanine-Cys-OH | pH 6.5, 30°C, strain 1b | Hepacivirus C | |
0.009 | - |
acetyl-Asp-(D-Glu)-(allyloxycarbonyl-L-lysine)-(L-cyclohexylalanine)-Cys-OH | pH 6.5, 30°C, strain 1a | Hepacivirus C | |
0.01 | - |
acetyl-Asp-(D-Glu)-(allyloxycarbonyl-L-lysine)-(L-cyclohexylalanine)-Cys-OH | pH 6.5, 30°C, strain 1a, mutant enzyme D168Q | Hepacivirus C | |
0.01 | - |
acetyl-Asp-(D-Glu)-(allyloxycarbonyl-L-lysine)-(L-cyclohexylalanine)-Cys-OH | pH 6.5, 30°C, strain 1b | Hepacivirus C | |
0.01 | - |
acetyl-Asp-(D-Glu)-Tyr-Ile-L-cyclohexylalanine-Cys-OH | pH 6.5, 30°C, strain 3a | Hepacivirus C | |
0.01 | - |
acetyl-Asp-(D-Glu)-(allyloxycarbonyl-L-lysine)-(L-cyclohexylalanine)-Cys-OH | pH 6.5, 30°C, strain 3a, mutant enzyme T123R/Q168D | Hepacivirus C | |
0.013 | - |
acetyl-Asp-(D-Glu)-Tyr-Ile-L-cyclohexylalanine-Cys-OH | pH 6.5, 30°C, strain 3a, mutant enzyme Q168D | Hepacivirus C | |
0.013 | - |
acetyl-Asp-(D-Glu)-(allyloxycarbonyl-L-lysine)-(L-cyclohexylalanine)-Cys-OH | pH 6.5, 30°C, strain 3a, mutant enzyme T123R | Hepacivirus C | |
0.015 | - |
acetyl-Asp-(D-Glu)-Tyr-Ile-L-cyclohexylalanine-Cys-OH | pH 6.5, 30°C, strain 1a, mutant enzyme R123T | Hepacivirus C | |
0.016 | - |
acetyl-Asp-(D-glutamine)-Leu-Ile-L-cyclohexylalanine-Cys-OH | pH 6.5, 30°C, strain 1a | Hepacivirus C | |
0.018 | - |
acetyl-Asp-(D-homoleucine)-Leu-Ile-(L-cyclohexylalanine)-Cys-OH | pH 6.5, 30°C, strain 1a, mutant enzyme R123T | Hepacivirus C | |
0.018 | - |
acetyl-Asp-(D-Glu)-Tyr-Ile-L-cyclohexylalanine-Cys-OH | pH 6.5, 30°C, strain 1a, mutant enzyme R123T/D168Q | Hepacivirus C | |
0.018 | - |
acetyl-Asp-(D-homoleucine)-Leu-Ile-(L-cyclohexylalanine)-Cys-OH | pH 6.5, 30°C, strain 3a, mutant enzyme Q168D | Hepacivirus C | |
0.019 | - |
acetyl-Asp-(D-homoleucine)-Leu-Ile-(L-cyclohexylalanine)-Cys-OH | pH 6.5, 30°C, strain 1a | Hepacivirus C | |
0.019 | - |
acetyl-Asp-(D-homoleucine)-Leu-Ile-(L-cyclohexylalanine)-Cys-OH | pH 6.5, 30°C, strain 3a, mutant enzyme T123R | Hepacivirus C | |
0.02 | - |
acetyl-Asp-(D-Glu)-Leu-Ile-L-cyclohexylalanine-Cys-OH | pH 6.5, 30°C, strain 1a, mutant enzyme R123T | Hepacivirus C | |
0.02 | - |
acetyl-Asp-(D-homoleucine)-Leu-Ile-(L-cyclohexylalanine)-Cys-OH | pH 6.5, 30°C, strain 1a, mutant enzyme R123T/D168Q | Hepacivirus C | |
0.02 | - |
acetyl-Asp-(D-glutamine)-Leu-Ile-L-cyclohexylalanine-Cys-OH | pH 6.5, 30°C, strain 1b | Hepacivirus C | |
0.02 | - |
acetyl-Asp-(D-Glu)-Leu-Ile-L-cyclohexylalanine-Cys-OH | pH 6.5, 30°C, strain 3a, mutant enzyme Q168D | Hepacivirus C | |
0.02 | - |
acetyl-Asp-(D-glutamine)-Leu-Ile-L-cyclohexylalanine-Cys-OH | pH 6.5, 30°C, strain 3a, mutant enzyme Q168D | Hepacivirus C | |
0.021 | - |
acetyl-Asp-(D-glutamine)-Leu-Ile-L-cyclohexylalanine-Cys-OH | pH 6.5, 30°C, strain 1a, mutant enzyme D168Q | Hepacivirus C | |
0.021 | - |
acetyl-Asp-(D-glutamine)-Leu-Ile-L-cyclohexylalanine-Cys-OH | pH 6.5, 30°C, strain 1a, mutant enzyme R123T | Hepacivirus C | |
0.021 | - |
acetyl-Asp-(D-homoleucine)-Leu-Ile-(L-cyclohexylalanine)-Cys-OH | pH 6.5, 30°C, strain 3a | Hepacivirus C | |
0.022 | - |
acetyl-Asp-(D-homoleucine)-Leu-Ile-(L-cyclohexylalanine)-Cys-OH | pH 6.5, 30°C, strain 3a, mutant enzyme T123R/Q168D | Hepacivirus C | |
0.023 | - |
acetyl-Asp-(D-glutamine)-Leu-Ile-L-cyclohexylalanine-Cys-OH | pH 6.5, 30°C, strain 1a, mutant enzyme R123T/D168Q | Hepacivirus C | |
0.023 | - |
acetyl-Asp-(D-homoleucine)-Leu-Ile-(L-cyclohexylalanine)-Cys-OH | pH 6.5, 30°C, strain 1b | Hepacivirus C | |
0.023 | - |
acetyl-Asp-(D-glutamine)-Leu-Ile-L-cyclohexylalanine-Cys-OH | pH 6.5, 30°C, strain 3a | Hepacivirus C | |
0.024 | - |
acetyl-Asp-(D-homoleucine)-Leu-Ile-(L-cyclohexylalanine)-Cys-OH | pH 6.5, 30°C, strain 1a, mutant enzyme D168Q | Hepacivirus C | |
0.024 | - |
acetyl-Asp-(D-homoglutamate)-Leu-Ile-L-cyclohexylalanine-Cys-OH | pH 6.5, 30°C, strain 3a, mutant enzyme Q168D | Hepacivirus C | |
0.024 | - |
acetyl-Asp-(D-glutamine)-Leu-Ile-L-cyclohexylalanine-Cys-OH | pH 6.5, 30°C, strain 3a, mutant enzyme T12 3R | Hepacivirus C | |
0.025 | - |
acetyl-Asp-(D-homoglutamate)-Leu-Ile-L-cyclohexylalanine-Cys-OH | pH 6.5, 30°C, strain 1a, mutant enzyme R123T | Hepacivirus C | |
0.025 | - |
acetyl-Asp-(D-Glu)-Leu-Ile-L-cyclohexylalanine-Cys-OH | pH 6.5, 30°C, strain 1a, mutant enzyme R123T/D168Q | Hepacivirus C | |
0.025 | - |
acetyl-Asp-(D-Glu)-Leu-Ile-L-cyclohexylalanine-Cys-OH | pH 6.5, 30°C, strain 3a | Hepacivirus C | |
0.025 | - |
acetyl-Asp-(D-glutamine)-Leu-Ile-L-cyclohexylalanine-Cys-OH | pH 6.5, 30°C, strain 3a, mutant enzyme T123R/Q168D | Hepacivirus C | |
0.03 | - |
acetyl-Asp-(D-homoglutamate)-Leu-Ile-L-cyclohexylalanine-Cys-OH | pH 6.5, 30°C, strain 1a, mutant enzyme R123T/D168Q | Hepacivirus C | |
0.03 | - |
acetyl-Asp-(D-homoglutamate)-Leu-Ile-L-cyclohexylalanine-Cys-OH | pH 6.5, 30°C, strain 3a | Hepacivirus C | |
0.04 | - |
acetyl-QSVVCC-OH | pH 6.5, 30°C, strain 1a | Hepacivirus C | |
0.04 | - |
acetyl-Asp-(D-Glu)-(allyloxycarbonyl-L-lysine)-(L-cyclohexylalanine)-Cys-OH | pH 6.5, 30°C, strain 3a | Hepacivirus C | |
0.04 | - |
acetyl-QSVVCC-OH | pH 6.5, 30°C, strain 3a | Hepacivirus C | |
0.045 | - |
acetyl-Asp-(D-Glu)-(allyloxycarbonyl-L-lysine)-(L-cyclohexylalanine)-Cys-OH | pH 6.5, 30°C, strain 3a, mutant enzyme Q168D | Hepacivirus C | |
0.05 | - |
acetyl-Asp-(D-Glu)-(allyloxycarbonyl-L-lysine)-(L-cyclohexylalanine)-Cys-OH | pH 6.5, 30°C, strain 1a, mutant enzyme R123T | Hepacivirus C | |
0.05 | - |
acetyl-QSVVCC-OH | pH 6.5, 30°C, strain 1b | Hepacivirus C | |
0.055 | - |
acetyl-Asp-(D-Glu)-(allyloxycarbonyl-L-lysine)-(L-cyclohexylalanine)-Cys-OH | pH 6.5, 30°C, strain 1a, mutant enzyme R123T/D168Q | Hepacivirus C | |
0.1 | - |
acetyl-EDVVCC-OH | pH 6.5, 30°C, strain 3a | Hepacivirus C | |
0.13 | - |
acetyl-EDVVCC-OH | pH 6.5, 30°C, strain 1a | Hepacivirus C | |
0.15 | - |
acetyl-EDVVCC-OH | pH 6.5, 30°C, strain 1b | Hepacivirus C | |
0.17 | - |
acetyl-DEMEEC-OH | pH 6.5, 30°C, strain 1b | Hepacivirus C | |
0.2 | - |
acetyl-DEMEEC-OH | pH 6.5, 30°C, strain 1a | Hepacivirus C | |
0.21 | - |
acetyl-DEMEEC-OH | pH 6.5, 30°C, strain 3a | Hepacivirus C | |
0.4 | - |
acetyl-DYPSPC-OH | pH 6.5, 30°C, strain 1b | Hepacivirus C | |
0.43 | - |
acetyl-DYPSPC-OH | pH 6.5, 30°C, strain 3a | Hepacivirus C | |
0.45 | - |
acetyl-DYPSPC-OH | pH 6.5, 30°C, strain 1a | Hepacivirus C | |
0.46 | - |
acetyl-ECTTPC-OH | pH 6.5, 30°C, strain 1b | Hepacivirus C | |
0.5 | - |
acetyl-ECTTPC-OH | pH 6.5, 30°C, strain 1a | Hepacivirus C | |
0.51 | - |
acetyl-ECTTPC-OH | pH 6.5, 30°C, strain 3a | Hepacivirus C |