Activating Compound | Comment | Organism | Structure |
---|---|---|---|
NS4A | - |
Hepacivirus C |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
acetyl-Asp-Glu-Val-Val-Pro-boroAlg-OH | the inhibitor binds in an antiparrallel manner to beta-strand E2 and interacts with the unprimed sites of the substrate binding pocket. In the NS3/NS4 inhibitor complex, the inhibitor behaves like a reaction intermediate analog. In the absence of the cofactor, inhibitor binding is an order of magnitude weaker | Hepacivirus C |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Hepacivirus C | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-Asp-Glu-Asp-(5-[(2'-aminoethyl)-amino]naphthalenesulfonic acid)-Glu-Glu-(alpha-aminobutyryl)PSI[COO]Ala-Ser-Lys-(4-[[4'-(dimethylamino)phenyl]azo]-benzoic acid)-NH2 + H2O | - |
Hepacivirus C | ? | - |
? |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.000013 | - |
acetyl-Asp-Glu-Val-Val-Pro-boroAlg-OH | - |
Hepacivirus C |