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Literature summary for 3.4.21.97 extracted from
- Release of the herpes simplex virus 1 protease by self cleavage is required for proper conformation of the portal vertex (2012), Virology, 429, 63-73.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| H61A | mutation impairs protease activity. Morphology of mutant capsids exclusively resembles those of procapsids or large cored B capsids. Specifically, mutant capsids are spherical and lack electron dense cores. Most of these particles are tightly clustered in the nucleoplasm. Mutant does not replicate to appreciable extents on CV1 cells | Herpes simplex virus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Herpes simplex virus | - |
- |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| HSV-1 protease | - |
Herpes simplex virus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | in a protease deletion mutant, capsids are assembled and portal protein is incorporated into capsids. Mutant does not replicate to appreciable extents on CV1 cells. The presence of the viral protease is required for immunoreactivity at the capsid surface with portal specific antibody | Herpes simplex virus |
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