Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.21.95 extracted from

  • Segers, K.; Dahlbaeck, B.; Bock, P.E.; Tans, G.; Rosing, J.; Nicolaes, G.A.
    The role of thrombin exosites I and II in the activation of human coagulation factor V (2007), J. Biol. Chem., 282, 33915-33924.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.95

Activating Compound

Activating Compound Comment Organism Structure
heparin at low concentrations, less than 5 units, binds heparin Daboia russelii
heparin at low concentrations, less than 5 units, binds heparin Macrovipera lebetina

Inhibitors

Inhibitors Comment Organism Structure
heparin at high concentrations, more than 100 units Daboia russelii
heparin at high concentrations, more than 100 units Macrovipera lebetina

Organism

Organism UniProt Comment Textmining
Daboia russelii
-
 Daboia ruscelli, RVV-V
-
Macrovipera lebetina
-
 Daboia lebetina turanica, LVV-V
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
human blood coagulation factor V + H2O snake venom proteases activates FV by a single cleavage at Arg1545, various mutated variants of blood coagulation factor V are used, snake venom protease require the C-terminal region of the B-domain for efficient activation of FV, this acidic region is importance for the recognition of the Arg1545 cleavage site by the venom FV activators Daboia russelii activated human blood coagulation factor V
-
 ?
human blood coagulation factor V + H2O snake venom proteases activates FV by a single cleavage at Arg1545, various mutated variants of blood coagulation factor V are used, snake venom protease require the C-terminal region of the B-domain for efficient activation of FV, this acidic region is importance for the recognition of the Arg1545 cleavage site by the venom FV activators Macrovipera lebetina activated human blood coagulation factor V
-
 ?

Synonyms

Synonyms Comment Organism
FV activating enzymes
-
 Daboia russelii
FV activating enzymes
-
 Macrovipera lebetina
Human blood coagulation Factor V activating enzymes
-
 Daboia russelii
Human blood coagulation Factor V activating enzymes
-
 Macrovipera lebetina
LVV-V
-
 Macrovipera lebetina
RVV-V
-
 Daboia russelii