Inhibitors | Comment | Organism | Structure |
---|---|---|---|
ClpS | adaptor protein ClpS is inhibitory to ClpC1. the unfolding rate of substrates shows a a nearly three-fold for conditions lacking ClpS relative to conditions with ClpS in excess | Mycobacterium tuberculosis |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mycobacterium tuberculosis | P9WPC9 | - |
- |
Mycobacterium tuberculosis H37Rv | P9WPC9 | - |
- |
Synonyms | Comment | Organism |
---|---|---|
ClpC1 | - |
Mycobacterium tuberculosis |
General Information | Comment | Organism |
---|---|---|
physiological function | ClpC1-catalyzed unfolding of an SsrA-tagged protein is negatively impacted by association with the ClpS adaptor protein. ClpS-dependent inhibition of ClpC1-catalyzed SsrA-dependent protein unfolding does not require the ClpC1 N-terminal domain but instead requires the presence of an interaction surface located in the ClpC1 middle domain | Mycobacterium tuberculosis |