Literature summary for 3.4.21.92 extracted from

Aguado, A.; Fernandez-Higuero, J.A.; Cabrera, Y.; Moro, F.; Muga, A.
ClpB dynamics is driven by its ATPase cycle and regulated by the DnaK system and substrate proteins (2015), Biochem. J., 466, 561-570 .

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Cloned(Commentary)

Cloned (Comment)	Organism
expression in Escherichia coli	Escherichia coli

Protein Variants

Protein Variants	Comment	Organism
S499C	mutation introduced for FRET measurements. Labelling of S499C with fluorescent probes induces a 10-20fold increase in both chaperone and ATPase activities	Escherichia coli

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	-	-	-
Escherichia coli BB4561	-	-	-

General Information

General Information	Comment	Organism
metabolism	presence of ATP favours assembly and ADP dissociation of the hexameric assembly. Subunit exchange kinetics is at least one order of magnitude slower than the ATP hydrolysis rate, and ClpB dynamics and activity are related processe. DnaK and substrate proteins regulate the ATPase activity and dynamics of ClpB	Escherichia coli

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Release 2023.1 (January 2023)