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Literature summary for 3.4.21.92 extracted from

  • Lin, W.; Chan, M.; Sim, T.S.
    Atypical caseinolytic protease homolog from Plasmodium falciparum possesses unusual substrate preference and a functional nuclear localization signal (2009), Parasitol. Res., 105, 1715-1722.
    View publication on PubMed
Search for more literature for 3.4.21.92

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21(DE3) cells Plasmodium falciparum

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
 Plasmodium falciparum 5634
-

Organism

Organism UniProt Comment Textmining
Plasmodium falciparum O97252 proteolytic subunit
-

Purification (Commentary)

Purification (Comment) Organism
glutathione-sepharose 4B bead column chromatography Plasmodium falciparum

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Gly-L-Arg-7-amido-4-methylcoumarin + H2O substrate for the recombinant ClpP Plasmodium falciparum Gly-L-Arg + 7-amino-4-methylcoumarin
-
 ?
additional information recombinant mature ClpP is not capable of hydrolyzing Gly-L-Arg-7-amido-4-methylcoumarin, Gly–L-Phe-7-amido-4-methylcoumarin, and benzyloxycarbonyl-L-Gln-L-Arg-L-Arg-7-amido-4-methylcoumarin. Mature ClpP protein does not cleave N-succinyl-L-leucine-L-tyrosine-7-amido-4-methylcoumarin and N-succinyl-L-isoleucine-L-isoleucine-L-tryptophan-7-amido-4-methylcoumarin Plasmodium falciparum ?
-
 ?
N-succinyl-L-isoleucine-L-isoleucine-L-tryptophan-7-amido-4-methylcoumarin + H2O
-
 Plasmodium falciparum ?
-
 ?
succinyl-L-Leu-L-Lys-7-amido-4-methylcoumarin + H2O recombinant mature ClpP is most active against succinyl-L-Leu-L-Lys-7-amido-4-methylcoumarin Plasmodium falciparum ?
-
 ?
succinyl-L-Leu-L-Tyr-7-amido-4-methylcoumarin + H2O recombinant ClpP does not cleave the known ClpP substrate succinyl-L-Leu-L-Tyr-7-amido-4-methylcoumarin Plasmodium falciparum succinyl-L-Leu-L-Tyr + 7-amino-4-methylcoumarin
-
 ?

Synonyms

Synonyms Comment Organism
Caseinolytic protease
-
 Plasmodium falciparum
CLP
-
 Plasmodium falciparum

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Plasmodium falciparum