Literature summary for 3.4.21.92 extracted from

Cao, J.; Gong, Y.; Li, D.; Yin, N.; Chen, T.; Xu, W.; Zhang, X.; Yin, Y.
CD4(+) T lymphocytes mediated protection against invasive pneumococcal infection induced by mucosal immunization with ClpP and CbpA (2009), Vaccine, 27, 2838-2844.

Search for more literature for 3.4.21.92

Application

Application	Comment	Organism
medicine	immunizing mice intranasally with a mixture of ClpP and CbpA (choline binding protein A) elicites better protection than that of immunizing either single ClpP or CbpA	Streptococcus pneumoniae TIGR4

Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	anti-infection activity and production of hyperimmune antibodies induced by mucosal immunization with ClpP and CbpA can be abrogated by the depletion of CD4+ T lymphocytes. Hyperimmune mouse sera against ClpP and CbpA can inhibit pneumococcus adhesion to cultured A549 epithelial cells and are efficiently opsonic for uptake and killing of pneumococcus by human polymorphonuclear leukocytes in a complement-dependent assay	Streptococcus pneumoniae TIGR4

Organism

Organism	UniProt	Comment	Textmining
Streptococcus pneumoniae TIGR4	P63787	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	nasal immunizations with ClpP and CbpA are efficient for induction of systemic and mucosal antibodies	Streptococcus pneumoniae TIGR4	?	-	?

Synonyms

Synonyms	Comment	Organism
Caseinolytic protease	-	Streptococcus pneumoniae TIGR4
ClpP	-	Streptococcus pneumoniae TIGR4

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)