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Literature summary for 3.4.21.92 extracted from

  • Frees, D.; Savijoki, K.; Varmanen, P.; Ingmer, H.
    Clp ATPases and ClpP proteolytic complexes regulate vital biological processes in low GC, Gram-positive bacteria (2007), Mol. Microbiol., 63, 1285-1295.
    View publication on PubMed
Search for more literature for 3.4.21.92

Organism

Organism UniProt Comment Textmining
Bacillus subtilis
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
COMK + H2O ClpCP, MecA required Bacillus subtilis ?
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 ?
MurAA + H2O MecA not required for degradation Bacillus subtilis ?
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 ?
RsiW + H2O ClXCP, AA at C-terminal as degradation tag Bacillus subtilis ?
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 ?
Sda + H2O ClpXP, VSS at C-terminal as degradation tag Bacillus subtilis ?
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 ?
SpollAB + H2O ClpCP, LCN at C-terminal as degradation tag, MecA not required, production of ClpP is strongly increased in response to heat shock or other stress signals, ClpP removes heat damaged proteins Bacillus subtilis ?
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 ?
Spx + H2O ClpCP, MecA or YpbH required for degradation Bacillus subtilis ?
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 ?
Spx + H2O ClpXP, LAN at C-terminal as degradation tag, MecA not required Bacillus subtilis ?
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 ?
SsrA tagged proteins + H2O ClpXP, AA at C-terminal as degradation tag Bacillus subtilis ?
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 ?

Subunits

Subunits Comment Organism
More 1400 ClpX hexamers, 250 ClpC heaxmers and 100 ClpE hexamers and 1200 ClpP tetramers are found in one cell during exponential growth at 37°C Bacillus subtilis

Synonyms

Synonyms Comment Organism
ClpP proteolytic complex Bacillus subtilis

Cofactor

Cofactor Comment Organism Structure
additional information MecA facilitates ClpC oligomerization into a complex containing both ClpC and MecA. Formation of this complex is a prerequisite for all ClpC mediated activities, including ATPase activity, substrate recognition and interaction with ClpP Bacillus subtilis