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Literature summary for 3.4.21.92 extracted from
- A peptide signal for adapter protein-mediated degradation by the AAA+ protease ClpCP (2007), Mol. Cell, 26, 639-647.
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bacillus subtilis | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| GFP-K17 fusion protein + H2O | - |
Bacillus subtilis | ? | - |
? |  |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ClpC ATPase | - |
Bacillus subtilis |
| ClpCP protease | - |
Bacillus subtilis |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| additional information | degradation of GFP-K17 is MecA dependent and prevented in the presence of ComS, MecA and ComS can be degraded by ClpCP. ComS competes with ComK for MecA binding and protects MecA from degradation by ClpP. The degradation of ComS requires the presence of MecA, which acts as an adapter for both ComS and ComK. MecA knockout strain fails to target ComK for degradation by ClpCP | Bacillus subtilis |
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