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Literature summary for 3.4.21.9 extracted from

  • Mikhailova, A.G.; Likhareva, V.V.; Prudchenko, I.A.; Rumsh, L.D.
    Effect of calcium ions on enteropeptidase catalysis (2005), Biochemistry (Moscow), 70, 1129-1135.
    View publication on PubMed
Search for more literature for 3.4.21.9

Inhibitors

Inhibitors Comment Organism Structure
Ca2+ slight inhibition of substrates with one or two Asp/Glu residues at P2-P3 positions Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.16
-
 GD4KF(NO2)G 50 mM Ca2+, pH 8.0, 37°C Homo sapiens
0.2
-
 glycyl-tetra-L-aspartyl-L-lysine beta-naphthylamide 50 mM Ca2+, pH 8.0, 37°C Homo sapiens
0.525
-
 glycyl-tetra-L-aspartyl-L-lysine beta-naphthylamide pH 8.0, 37°C Homo sapiens
596
-
 N-alpha-benzyloxycarbonyl-L-lysine thiobenzyl ester + 37°C, pH 8.0 Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ 50 mM, 3fold activation of hydrolysis of substrates of the general type GD4KX Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Trypsinogen + H2O Homo sapiens
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
G5DKF(NO2)G + H2O
-
 Homo sapiens ?
-
 ?
GD4KF(NO2)G + H2O
-
 Homo sapiens ?
-
 ?
glycyl-tetra-L-aspartyl-L-lysine beta-naphthylamide + H2O
-
 Homo sapiens glycyl-tetra-L-aspartyl-L-lysine + beta-naphthylamine
-
 ?
LTAEEKA + H2O
-
 Homo sapiens ?
-
 ?
LTAEEKAAV + H2O
-
 Homo sapiens ?
-
 ?
N-alpha-benzyloxycarbonyl-L-lysine thiobenzyl ester + H2O
-
 Homo sapiens N-alpha-benzyloxycarbonyl-L-lysine + benzylmercaptane
-
 ?
N-alpha-benzyloxycarbonyl-L-lysine thiobenzyl ester + H2O
-
 Homo sapiens N-alpha-benzyloxycarbonyl-L-lysine + phenylmethanethiol
-
 ?
Trypsinogen + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
EP 118-1035
-
 Homo sapiens
natural enteropeptidase
-
 Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.07
-
 LTAEEKA pH 8.0, 37°C Homo sapiens
0.97
-
 G5DKF(NO2)G 50 mM Ca2+, pH 8.0, 37°C Homo sapiens
0.97
-
 glycyl-tetra-L-aspartyl-L-lysine beta-naphthylamide 50 mM Ca2+, pH 8.0, 37°C Homo sapiens
0.99
-
 GD4KF(NO2)G 50 mM Ca2+, pH 8.0, 37°C Homo sapiens
16.67
-
 glycyl-tetra-L-aspartyl-L-lysine beta-naphthylamide 50 mM Ca2+, pH 8.0, 37°C Homo sapiens
17.33
-
 G5DKF(NO2)G 50 mM Ca2+, pH 8.0, 37°C Homo sapiens
17.83
-
 GD4KF(NO2)G 50 mM Ca2+, pH 8.0, 37°C Homo sapiens
21.5
-
 glycyl-tetra-L-aspartyl-L-lysine beta-naphthylamide pH 8.0, 37°C Homo sapiens
111
-
 N-alpha-benzyloxycarbonyl-L-lysine thiobenzyl ester 37°C, pH 8.0 Homo sapiens