Literature summary for 3.4.21.89 extracted from

Schallenberger, M.A.; Niessen, S.; Shao, C.; Fowler, B.J.; Romesberg, F.E.
Type I signal peptidase and protein secretion in Staphylococcus aureus (2012), J. Bacteriol., 194, 2677-2686.

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Inhibitors

Inhibitors	Comment	Organism	Structure
arylomycin A-C16	secretion of proteins HtrA, PrsA, and SAOUHSC_01761 is induced by inhibitor treatment	Staphylococcus aureus

Organism

Organism	UniProt	Comment	Textmining
Staphylococcus aureus	-	-	-
Staphylococcus aureus NCTC 8325	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
lipoteichoic acid synthase + H2O	-	Staphylococcus aureus	?	soluble C-terminal domain has a noncanonical, internal cleavage site	?
lipoteichoic acid synthase + H2O	-	Staphylococcus aureus NCTC 8325	?	soluble C-terminal domain has a noncanonical, internal cleavage site	?
additional information	identification of 46 proteins whose extracellular accumulation requires signal peptidase activity. Forty-four possess identifiable Sec-type signal peptides and thus are likely canonically secreted proteins, while four also appear to possess cell wall retention signals. For three proteins, HtrA, PrsA, and SAOUHSC_01761, secretion is induced by inhibitor arylomycin treatment	Staphylococcus aureus	?	-	?
additional information	identification of 46 proteins whose extracellular accumulation requires signal peptidase activity. Forty-four possess identifiable Sec-type signal peptides and thus are likely canonically secreted proteins, while four also appear to possess cell wall retention signals. For three proteins, HtrA, PrsA, and SAOUHSC_01761, secretion is induced by inhibitor arylomycin treatment	Staphylococcus aureus NCTC 8325	?	-	?
O-acetyltransferase + H2O	-	Staphylococcus aureus	?	soluble C-terminal domain has a noncanonical, internal cleavage site	?
O-acetyltransferase + H2O	-	Staphylococcus aureus NCTC 8325	?	soluble C-terminal domain has a noncanonical, internal cleavage site	?

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Release 2023.1 (January 2023)