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Literature summary for 3.4.21.89 extracted from

  • Kulanthaivel, P.; Kreuzman, A.J.; Strege, M.A.; Belvo, M.D.; Smitka, T.A.; Clemens, M.; Swartling, J.R.; Minton, K.L.; Zheng, F.; Angleton, E.L.; Mullen, D.; Jungheim, L.N.; Klimkowski, V.J.; Nicas, T.I.; Thompson, R.C.; Peng, S.B.
    Novel lipoglycopeptides as inhibitors of bacterial signal peptidase I (2004), J. Biol. Chem., 279, 36250-36258.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
N-hexadecanoyl-N-methylserylalanyl-N-[13-carboxy-3-[(6-deoxyhexopyranosyl)oxy]-4,18-dihydroxy-10-methyl-8,11-dioxo-9,12-diazatricyclo[13.3.1.12,6]icosa-1(19),2(20),3,5,15,17-hexaen-7-yl]-N-methylglycinamide IC50: 190 nM Escherichia coli
N-hexadecanoyl-N-methylserylalanyl-N-[13-carboxy-3-[(6-deoxyhexopyranosyl)oxy]-4,18-dihydroxy-10-methyl-8,11-dioxo-9,12-diazatricyclo[13.3.1.12,6]icosa-1(19),2(20),3,5,15,17-hexaen-7-yl]-N-methylglycinamide
-
Streptococcus pneumoniae
N-methyl-N-(12-methyltridecanoyl)serylalanyl-N-[13-carboxy-3-[(6-deoxyhexopyranosyl)oxy]-18-hydroxy-10-methyl-8,11-dioxo-9,12-diazatricyclo[13.3.1.12,6]icosa-1(19),2(20),3,5,15,17-hexaen-7-yl]-N-methylglycinamide IC50: 110 nM Escherichia coli
N-methyl-N-(12-methyltridecanoyl)serylalanyl-N-[13-carboxy-3-[(6-deoxyhexopyranosyl)oxy]-18-hydroxy-10-methyl-8,11-dioxo-9,12-diazatricyclo[13.3.1.12,6]icosa-1(19),2(20),3,5,15,17-hexaen-7-yl]-N-methylglycinamide
-
Streptococcus pneumoniae
N-methyl-N-(12-methyltridecanoyl)serylalanyl-N-[13-carboxy-3-[(6-deoxyhexopyranosyl)oxy]-4,18-dihydroxy-10-methyl-8,11-dioxo-9,12-diazatricyclo[13.3.1.12,6]icosa-1(19),2(20),3,5,15,17-hexaen-7-yl]-N-methylglycinamide IC50: 110 nM Escherichia coli
N-methyl-N-(12-methyltridecanoyl)serylalanyl-N-[13-carboxy-3-[(6-deoxyhexopyranosyl)oxy]-4,18-dihydroxy-10-methyl-8,11-dioxo-9,12-diazatricyclo[13.3.1.12,6]icosa-1(19),2(20),3,5,15,17-hexaen-7-yl]-N-methylglycinamide
-
Streptococcus pneumoniae
N-methyl-N-(13-methyltetradecanoyl)serylalanyl-N-[13-carboxy-3-[(6-deoxyhexopyranosyl)oxy]-18-hydroxy-10-methyl-8,11-dioxo-9,12-diazatricyclo[13.3.1.12,6]icosa-1(19),2(20),3,5,15,17-hexaen-7-yl]-N-methylglycinamide IC50: 130 nM Escherichia coli
N-methyl-N-(13-methyltetradecanoyl)serylalanyl-N-[13-carboxy-3-[(6-deoxyhexopyranosyl)oxy]-18-hydroxy-10-methyl-8,11-dioxo-9,12-diazatricyclo[13.3.1.12,6]icosa-1(19),2(20),3,5,15,17-hexaen-7-yl]-N-methylglycinamide
-
Streptococcus pneumoniae
N-methyl-N-(14-methylpentadecanoyl)serylalanyl-N-[13-carboxy-3-[(6-deoxyhexopyranosyl)oxy]-18-hydroxy-10-methyl-8,11-dioxo-9,12-diazatricyclo[13.3.1.12,6]icosa-1(19),2(20),3,5,15,17-hexaen-7-yl]-N-methylglycinamide IC50: 130 nM Escherichia coli
N-methyl-N-(14-methylpentadecanoyl)serylalanyl-N-[13-carboxy-3-[(6-deoxyhexopyranosyl)oxy]-18-hydroxy-10-methyl-8,11-dioxo-9,12-diazatricyclo[13.3.1.12,6]icosa-1(19),2(20),3,5,15,17-hexaen-7-yl]-N-methylglycinamide
-
Streptococcus pneumoniae
N-methyl-N-(14-methylpentadecanoyl)serylalanyl-N-[13-carboxy-3-[(6-deoxyhexopyranosyl)oxy]-4,18-dihydroxy-10-methyl-8,11-dioxo-9,12-diazatricyclo[13.3.1.12,6]icosa-1(19),2(20),3,5,15,17-hexaen-7-yl]-N-methylglycinamide IC50: 170 nM Escherichia coli
N-methyl-N-(14-methylpentadecanoyl)serylalanyl-N-[13-carboxy-3-[(6-deoxyhexopyranosyl)oxy]-4,18-dihydroxy-10-methyl-8,11-dioxo-9,12-diazatricyclo[13.3.1.12,6]icosa-1(19),2(20),3,5,15,17-hexaen-7-yl]-N-methylglycinamide
-
Streptococcus pneumoniae
N-methyl-N-pentadecanoylserylalanyl-N-[13-carboxy-3-[(6-deoxyhexopyranosyl)oxy]-18-hydroxy-10-methyl-8,11-dioxo-9,12-diazatricyclo[13.3.1.12,6]icosa-1(19),2(20),3,5,15,17-hexaen-7-yl]-N-methylglycinamide IC50: 130 nM Escherichia coli
N-methyl-N-pentadecanoylserylalanyl-N-[13-carboxy-3-[(6-deoxyhexopyranosyl)oxy]-18-hydroxy-10-methyl-8,11-dioxo-9,12-diazatricyclo[13.3.1.12,6]icosa-1(19),2(20),3,5,15,17-hexaen-7-yl]-N-methylglycinamide
-
Streptococcus pneumoniae
N-methyl-N-tetradecanoylserylalanyl-N-[13-carboxy-3-[(6-deoxyhexopyranosyl)oxy]-18-hydroxy-10-methyl-8,11-dioxo-9,12-diazatricyclo[13.3.1.12,6]icosa-1(19),2(20),3,5,15,17-hexaen-7-yl]-N-methylglycinamide IC50: 110 nM Escherichia coli
N-methyl-N-tetradecanoylserylalanyl-N-[13-carboxy-3-[(6-deoxyhexopyranosyl)oxy]-18-hydroxy-10-methyl-8,11-dioxo-9,12-diazatricyclo[13.3.1.12,6]icosa-1(19),2(20),3,5,15,17-hexaen-7-yl]-N-methylglycinamide
-
Streptococcus pneumoniae

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-
Streptococcus pneumoniae
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Escherichia coli
-
Streptococcus pneumoniae

Synonyms

Synonyms Comment Organism
Spase I
-
Escherichia coli
Spase I
-
Streptococcus pneumoniae

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00005
-
N-methyl-N-(12-methyltridecanoyl)serylalanyl-N-[13-carboxy-3-[(6-deoxyhexopyranosyl)oxy]-18-hydroxy-10-methyl-8,11-dioxo-9,12-diazatricyclo[13.3.1.12,6]icosa-1(19),2(20),3,5,15,17-hexaen-7-yl]-N-methylglycinamide
-
Escherichia coli
0.000058
-
N-methyl-N-(14-methylpentadecanoyl)serylalanyl-N-[13-carboxy-3-[(6-deoxyhexopyranosyl)oxy]-18-hydroxy-10-methyl-8,11-dioxo-9,12-diazatricyclo[13.3.1.12,6]icosa-1(19),2(20),3,5,15,17-hexaen-7-yl]-N-methylglycinamide
-
Escherichia coli
0.00011
-
N-methyl-N-(12-methyltridecanoyl)serylalanyl-N-[13-carboxy-3-[(6-deoxyhexopyranosyl)oxy]-4,18-dihydroxy-10-methyl-8,11-dioxo-9,12-diazatricyclo[13.3.1.12,6]icosa-1(19),2(20),3,5,15,17-hexaen-7-yl]-N-methylglycinamide
-
Escherichia coli
0.000158
-
N-hexadecanoyl-N-methylserylalanyl-N-[13-carboxy-3-[(6-deoxyhexopyranosyl)oxy]-4,18-dihydroxy-10-methyl-8,11-dioxo-9,12-diazatricyclo[13.3.1.12,6]icosa-1(19),2(20),3,5,15,17-hexaen-7-yl]-N-methylglycinamide
-
Escherichia coli

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00011
-
IC50: 110 nM Escherichia coli N-methyl-N-(12-methyltridecanoyl)serylalanyl-N-[13-carboxy-3-[(6-deoxyhexopyranosyl)oxy]-18-hydroxy-10-methyl-8,11-dioxo-9,12-diazatricyclo[13.3.1.12,6]icosa-1(19),2(20),3,5,15,17-hexaen-7-yl]-N-methylglycinamide
0.00011
-
IC50: 110 nM Escherichia coli N-methyl-N-(12-methyltridecanoyl)serylalanyl-N-[13-carboxy-3-[(6-deoxyhexopyranosyl)oxy]-4,18-dihydroxy-10-methyl-8,11-dioxo-9,12-diazatricyclo[13.3.1.12,6]icosa-1(19),2(20),3,5,15,17-hexaen-7-yl]-N-methylglycinamide
0.00011
-
IC50: 110 nM Escherichia coli N-methyl-N-tetradecanoylserylalanyl-N-[13-carboxy-3-[(6-deoxyhexopyranosyl)oxy]-18-hydroxy-10-methyl-8,11-dioxo-9,12-diazatricyclo[13.3.1.12,6]icosa-1(19),2(20),3,5,15,17-hexaen-7-yl]-N-methylglycinamide
0.00013
-
IC50: 130 nM Escherichia coli N-methyl-N-(14-methylpentadecanoyl)serylalanyl-N-[13-carboxy-3-[(6-deoxyhexopyranosyl)oxy]-18-hydroxy-10-methyl-8,11-dioxo-9,12-diazatricyclo[13.3.1.12,6]icosa-1(19),2(20),3,5,15,17-hexaen-7-yl]-N-methylglycinamide
0.00013
-
IC50: 130 nM Escherichia coli N-methyl-N-(13-methyltetradecanoyl)serylalanyl-N-[13-carboxy-3-[(6-deoxyhexopyranosyl)oxy]-18-hydroxy-10-methyl-8,11-dioxo-9,12-diazatricyclo[13.3.1.12,6]icosa-1(19),2(20),3,5,15,17-hexaen-7-yl]-N-methylglycinamide
0.00013
-
IC50: 130 nM Escherichia coli N-methyl-N-pentadecanoylserylalanyl-N-[13-carboxy-3-[(6-deoxyhexopyranosyl)oxy]-18-hydroxy-10-methyl-8,11-dioxo-9,12-diazatricyclo[13.3.1.12,6]icosa-1(19),2(20),3,5,15,17-hexaen-7-yl]-N-methylglycinamide
0.00017
-
IC50: 170 nM Escherichia coli N-methyl-N-(14-methylpentadecanoyl)serylalanyl-N-[13-carboxy-3-[(6-deoxyhexopyranosyl)oxy]-4,18-dihydroxy-10-methyl-8,11-dioxo-9,12-diazatricyclo[13.3.1.12,6]icosa-1(19),2(20),3,5,15,17-hexaen-7-yl]-N-methylglycinamide
0.00019
-
IC50: 190 nM Escherichia coli N-hexadecanoyl-N-methylserylalanyl-N-[13-carboxy-3-[(6-deoxyhexopyranosyl)oxy]-4,18-dihydroxy-10-methyl-8,11-dioxo-9,12-diazatricyclo[13.3.1.12,6]icosa-1(19),2(20),3,5,15,17-hexaen-7-yl]-N-methylglycinamide