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Literature summary for 3.4.21.89 extracted from

  • Geukens, N.; Frederix, F.; Reekmans, G.; Lammertyn, E.; Van Mellaert, L.; Dehaen, W.; Maes, G.; Anne, J.
    Analysis of type I signal peptidase affinity and specificity for preprotein substrates (2004), Biochem. Biophys. Res. Commun., 314, 459-467.
    View publication on PubMed
Search for more literature for 3.4.21.89

Application

Application Comment Organism
pharmacology enzyme is essential for bacterial cell viability, potential molecular target for development of novel antibacterial agents Escherichia coli

Localization

Localization Comment Organism GeneOntology No. Textmining
plasma membrane membrane-bound, carboxyterminal catalytic region which resides in the periplasmic space Escherichia coli 5886
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
signal peptides from preproteins + H2O Streptomyces lividans
-
 mature proteins
-
 ?
signal peptides from preproteins + H2O Escherichia coli in vivo, type I signal peptidase is the principal peptidase responsible for signal peptide cleavage as pre-proteins of a number of exported proteins, proteins designed for transport across the cytoplasmic membrane are generally synthesised as precursors with cleavable signal peptides in the cytoplasm, the signal peptides targets the pre-proteins to the respective translocase, during or shortly after translocation across the cytoplasmic membrane, the signal peptide is enzymatically removed mature proteins
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli
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 strains TG1 and BL21(DE3)pLysS
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Streptomyces lividans
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Escherichia coli
-
 Streptomyces lividans

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
signal peptides from preproteins + H2O
-
 Escherichia coli mature proteins
-
 ?
signal peptides from preproteins + H2O
-
 Streptomyces lividans mature proteins
-
 ?
signal peptides from preproteins + H2O in vivo, type I signal peptidase is the principal peptidase responsible for signal peptide cleavage as pre-proteins of a number of exported proteins, proteins designed for transport across the cytoplasmic membrane are generally synthesised as precursors with cleavable signal peptides in the cytoplasm, the signal peptides targets the pre-proteins to the respective translocase, during or shortly after translocation across the cytoplasmic membrane, the signal peptide is enzymatically removed Escherichia coli mature proteins
-
 ?
VsiSP-mTNFalpha + H2O
-
 Streptomyces lividans ?
-
 ?

Synonyms

Synonyms Comment Organism
SipY
-
 Streptomyces lividans