Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | a mutant maltose-binding protein species with Pro at the +1 position interferes with the activity of signal peptidase in vivo, the mutant protein is not processed at either the normal site or an upstream alternate site previously identified, induced synthesis of this protein is inhibitory to cell growth and causes a pleiotrophic defect in processing of all nonlipoprotein precursors examined | Escherichia coli |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
chloroplast stroma | - |
Pisum sativum | 9570 | - |
cytoplasmic membrane | bacteria | Escherichia coli | - |
- |
endoplasmic reticulum | rough ER microsomes | Gallus gallus | 5783 | - |
endoplasmic reticulum | rough ER microsomes | Saccharomyces cerevisiae | 5783 | - |
endoplasmic reticulum | rough ER microsomes | Canis lupus familiaris | 5783 | - |
mitochondrial inner membrane | - |
Saccharomyces cerevisiae | 5743 | - |
mitochondrial matrix | - |
Rattus norvegicus | 5759 | - |
mitochondrial matrix | - |
Saccharomyces cerevisiae | 5759 | - |
mitochondrial matrix | - |
Neurospora crassa | 5759 | - |
thylakoid | - |
Pisum sativum | 9579 | - |
thylakoid | chloroplast | Pisum sativum | 9579 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
12000 | - |
1 * 25000 + 1 * 22000-23000 (a glycoprotein) + 1 * 21000 + 1 * 18000 + 1 * 12000, dog, SDS-PAGE | Canis lupus familiaris |
13000 | - |
1 * 18000 + 1 * 20000 + 1 * 25000 + 1 * 13000 (the association of the 13000 MW protein with the enzymatic activity is tentative), yeast, SDS-PAGE | Escherichia coli |
13000 | - |
1 * 18000 + 1 * 20000 + 1 * 25000 + 1 * 13000 (the association of the 13000 MW protein with the enzymatic activity is tentative), yeast, SDS-PAGE | Saccharomyces cerevisiae |
18000 | - |
1 * 25000 + 1 * 22000-23000 (a glycoprotein) + 1 * 21000 + 1 * 18000 + 1 * 12000, dog, SDS-PAGE | Canis lupus familiaris |
18000 | - |
1 * 18000 + 1 * 20000 + 1 * 25000 + 1 * 13000 (the association of the 13000 MW protein with the enzymatic activity is tentative), yeast, SDS-PAGE | Escherichia coli |
18000 | - |
1 * 18000 + 1 * 20000 + 1 * 25000 + 1 * 13000 (the association of the 13000 MW protein with the enzymatic activity is tentative), yeast, SDS-PAGE | Saccharomyces cerevisiae |
19000 | - |
1 * 22000-23000 + 1 * 19000, chicken, SDS-PAGE | Gallus gallus |
19000 | - |
1 * 22000-23000 + 1 * 19000, chicken, SDS-PAGE | Rattus norvegicus |
19000 | - |
1 * 22000-23000 + 1 * 19000, chicken, SDS-PAGE | Saccharomyces cerevisiae |
19000 | - |
1 * 22000-23000 + 1 * 19000, chicken, SDS-PAGE | Neurospora crassa |
20000 | - |
1 * 18000 + 1 * 20000 + 1 * 25000 + 1 * 13000 (the association of the 13000 MW protein with the enzymatic activity is tentative), yeast, SDS-PAGE | Escherichia coli |
20000 | - |
1 * 18000 + 1 * 20000 + 1 * 25000 + 1 * 13000 (the association of the 13000 MW protein with the enzymatic activity is tentative), yeast, SDS-PAGE | Saccharomyces cerevisiae |
21000 | - |
1 * 25000 + 1 * 22000-23000 (a glycoprotein) + 1 * 21000 + 1 * 18000 + 1 * 12000, dog, SDS-PAGE | Canis lupus familiaris |
25000 | - |
1 * 25000 + 1 * 22000-23000 (a glycoprotein) + 1 * 21000 + 1 * 18000 + 1 * 12000, dog, SDS-PAGE | Canis lupus familiaris |
25000 | - |
1 * 18000 + 1 * 20000 + 1 * 25000 + 1 * 13000 (the association of the 13000 MW protein with the enzymatic activity is tentative), yeast, SDS-PAGE | Escherichia coli |
25000 | - |
1 * 18000 + 1 * 20000 + 1 * 25000 + 1 * 13000 (the association of the 13000 MW protein with the enzymatic activity is tentative), yeast, SDS-PAGE | Saccharomyces cerevisiae |
48000 | - |
1 * 51000 + 1 * 48000, yeast, SDS-PAGE | Gallus gallus |
48000 | - |
1 * 51000 + 1 * 48000, yeast, SDS-PAGE | Rattus norvegicus |
48000 | - |
1 * 51000 + 1 * 48000, yeast, SDS-PAGE | Saccharomyces cerevisiae |
48000 | - |
1 * 51000 + 1 * 48000, yeast, SDS-PAGE | Neurospora crassa |
51000 | - |
1 * 51000 + 1 * 48000, yeast, SDS-PAGE | Gallus gallus |
51000 | - |
1 * 51000 + 1 * 48000, yeast, SDS-PAGE | Rattus norvegicus |
51000 | - |
1 * 51000 + 1 * 48000, yeast, SDS-PAGE | Saccharomyces cerevisiae |
51000 | - |
1 * 51000 + 1 * 48000, yeast, SDS-PAGE | Neurospora crassa |
52000 | - |
1 * 57000 + 1 * 52000, Neurospora crassa, SDS-PAGE | Gallus gallus |
52000 | - |
1 * 57000 + 1 * 52000, Neurospora crassa, SDS-PAGE | Rattus norvegicus |
52000 | - |
1 * 57000 + 1 * 52000, Neurospora crassa, SDS-PAGE | Saccharomyces cerevisiae |
52000 | - |
1 * 57000 + 1 * 52000, Neurospora crassa, SDS-PAGE | Neurospora crassa |
52000 | - |
1 * 52000 + 1 * 55000, SDS-PAGE | Gallus gallus |
52000 | - |
1 * 52000 + 1 * 55000, SDS-PAGE | Rattus norvegicus |
52000 | - |
1 * 52000 + 1 * 55000, SDS-PAGE | Saccharomyces cerevisiae |
52000 | - |
1 * 52000 + 1 * 55000, SDS-PAGE | Neurospora crassa |
55000 | - |
1 * 52000 + 1 * 55000, SDS-PAGE | Gallus gallus |
55000 | - |
1 * 52000 + 1 * 55000, SDS-PAGE | Rattus norvegicus |
55000 | - |
1 * 52000 + 1 * 55000, SDS-PAGE | Saccharomyces cerevisiae |
55000 | - |
1 * 52000 + 1 * 55000, SDS-PAGE | Neurospora crassa |
57000 | - |
1 * 57000 + 1 * 52000, Neurospora crassa, SDS-PAGE | Gallus gallus |
57000 | - |
1 * 57000 + 1 * 52000, Neurospora crassa, SDS-PAGE | Rattus norvegicus |
57000 | - |
1 * 57000 + 1 * 52000, Neurospora crassa, SDS-PAGE | Saccharomyces cerevisiae |
57000 | - |
1 * 57000 + 1 * 52000, Neurospora crassa, SDS-PAGE | Neurospora crassa |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Canis lupus familiaris | - |
- |
- |
Escherichia coli | - |
- |
- |
Gallus gallus | - |
- |
- |
Neurospora crassa | - |
- |
- |
Pisum sativum | - |
pea | - |
Rattus norvegicus | - |
- |
- |
Saccharomyces cerevisiae | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
oviduct | - |
Gallus gallus | - |
pancreas | - |
Canis lupus familiaris | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | specificity overview | Gallus gallus | ? | - |
? | |
additional information | specificity overview | Escherichia coli | ? | - |
? | |
additional information | specificity overview | Rattus norvegicus | ? | - |
? | |
additional information | specificity overview | Saccharomyces cerevisiae | ? | - |
? | |
additional information | specificity overview | Neurospora crassa | ? | - |
? | |
additional information | specificity overview | Pisum sativum | ? | - |
? | |
additional information | specificity overview | Canis lupus familiaris | ? | - |
? | |
additional information | a typical signal sequence is 15-25 amino acids long, it has a tripartite structure consisting of a positively charged NH2-terminal region (n-region, 1-5 amino acids), a central hydrophobic core (h-region, 7-15 amino acids) probably arranged in a alpha-helix, and, separated by an alpha-helix breaking Pro or Gly, the more polar part (c-region, 3-7 amino acids), representing half of the cleavage site | Gallus gallus | ? | - |
? | |
additional information | a typical signal sequence is 15-25 amino acids long, it has a tripartite structure consisting of a positively charged NH2-terminal region (n-region, 1-5 amino acids), a central hydrophobic core (h-region, 7-15 amino acids) probably arranged in a alpha-helix, and, separated by an alpha-helix breaking Pro or Gly, the more polar part (c-region, 3-7 amino acids), representing half of the cleavage site | Escherichia coli | ? | - |
? | |
additional information | a typical signal sequence is 15-25 amino acids long, it has a tripartite structure consisting of a positively charged NH2-terminal region (n-region, 1-5 amino acids), a central hydrophobic core (h-region, 7-15 amino acids) probably arranged in a alpha-helix, and, separated by an alpha-helix breaking Pro or Gly, the more polar part (c-region, 3-7 amino acids), representing half of the cleavage site | Rattus norvegicus | ? | - |
? | |
additional information | a typical signal sequence is 15-25 amino acids long, it has a tripartite structure consisting of a positively charged NH2-terminal region (n-region, 1-5 amino acids), a central hydrophobic core (h-region, 7-15 amino acids) probably arranged in a alpha-helix, and, separated by an alpha-helix breaking Pro or Gly, the more polar part (c-region, 3-7 amino acids), representing half of the cleavage site | Saccharomyces cerevisiae | ? | - |
? | |
additional information | a typical signal sequence is 15-25 amino acids long, it has a tripartite structure consisting of a positively charged NH2-terminal region (n-region, 1-5 amino acids), a central hydrophobic core (h-region, 7-15 amino acids) probably arranged in a alpha-helix, and, separated by an alpha-helix breaking Pro or Gly, the more polar part (c-region, 3-7 amino acids), representing half of the cleavage site | Neurospora crassa | ? | - |
? | |
additional information | a typical signal sequence is 15-25 amino acids long, it has a tripartite structure consisting of a positively charged NH2-terminal region (n-region, 1-5 amino acids), a central hydrophobic core (h-region, 7-15 amino acids) probably arranged in a alpha-helix, and, separated by an alpha-helix breaking Pro or Gly, the more polar part (c-region, 3-7 amino acids), representing half of the cleavage site | Pisum sativum | ? | - |
? | |
additional information | a typical signal sequence is 15-25 amino acids long, it has a tripartite structure consisting of a positively charged NH2-terminal region (n-region, 1-5 amino acids), a central hydrophobic core (h-region, 7-15 amino acids) probably arranged in a alpha-helix, and, separated by an alpha-helix breaking Pro or Gly, the more polar part (c-region, 3-7 amino acids), representing half of the cleavage site | Canis lupus familiaris | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | 1 * 18000 + 1 * 20000 + 1 * 25000 + 1 * 13000 (the association of the 13000 MW protein with the enzymatic activity is tentative), yeast, SDS-PAGE | Escherichia coli |
? | 1 * 18000 + 1 * 20000 + 1 * 25000 + 1 * 13000 (the association of the 13000 MW protein with the enzymatic activity is tentative), yeast, SDS-PAGE | Saccharomyces cerevisiae |
dimer | 1 * 22000-23000 + 1 * 19000, chicken, SDS-PAGE | Gallus gallus |
dimer | 1 * 22000-23000 + 1 * 19000, chicken, SDS-PAGE | Rattus norvegicus |
dimer | 1 * 22000-23000 + 1 * 19000, chicken, SDS-PAGE | Saccharomyces cerevisiae |
dimer | 1 * 22000-23000 + 1 * 19000, chicken, SDS-PAGE | Neurospora crassa |
dimer | 1 * 51000 + 1 * 48000, yeast, SDS-PAGE | Gallus gallus |
dimer | 1 * 51000 + 1 * 48000, yeast, SDS-PAGE | Rattus norvegicus |
dimer | 1 * 51000 + 1 * 48000, yeast, SDS-PAGE | Saccharomyces cerevisiae |
dimer | 1 * 51000 + 1 * 48000, yeast, SDS-PAGE | Neurospora crassa |
dimer | 1 * 57000 + 1 * 52000, Neurospora crassa, SDS-PAGE | Gallus gallus |
dimer | 1 * 57000 + 1 * 52000, Neurospora crassa, SDS-PAGE | Rattus norvegicus |
dimer | 1 * 57000 + 1 * 52000, Neurospora crassa, SDS-PAGE | Saccharomyces cerevisiae |
dimer | 1 * 57000 + 1 * 52000, Neurospora crassa, SDS-PAGE | Neurospora crassa |
dimer | 1 * 52000 + 1 * 55000, SDS-PAGE | Gallus gallus |
dimer | 1 * 52000 + 1 * 55000, SDS-PAGE | Rattus norvegicus |
dimer | 1 * 52000 + 1 * 55000, SDS-PAGE | Saccharomyces cerevisiae |
dimer | 1 * 52000 + 1 * 55000, SDS-PAGE | Neurospora crassa |
pentamer | 1 * 25000 + 1 * 22000-23000 (a glycoprotein) + 1 * 21000 + 1 * 18000 + 1 * 12000, dog, SDS-PAGE | Canis lupus familiaris |