Literature summary for 3.4.21.88 extracted from

Schons-Fonseca, L.; Da Silva, J.; Milanez, J.; Domingos, R.; Smith, J.; Nakaya, H.; Grossman, A.; Ho, P.; Da Costa, R.
Analysis of LexA binding sites and transcriptomics in response to genotoxic stress in Leptospira interrogans (2016), Nucleic Acids Res., 44, 1179-1191 .

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Organism

Organism	UniProt	Comment	Textmining
Leptospira interrogans serovar Copenhageni	M3G1T5	-	-
Leptospira interrogans serovar Copenhageni LT2050	M3G1T5	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	genome-wide mapping of LexA1 binding sites using ChIP-qPCR, determination of genes directly associated with LexA1 binding sites, overview. the LexA1 binding site is a 16 nt palindrome whose consensus is roughly CTnnACnnnnGTnnAG, it is present in all sequences shown to bind to LexA1 in serovar Copenhageni. Almost every peak of LexA1 binding is located upstream of a gene, in potential regulatory regions. LexA1-bound genes show decreased or no differential expression after DNA damage	Leptospira interrogans serovar Copenhageni	?	-	?
additional information	genome-wide mapping of LexA1 binding sites using ChIP-qPCR, determination of genes directly associated with LexA1 binding sites, overview. the LexA1 binding site is a 16 nt palindrome whose consensus is roughly CTnnACnnnnGTnnAG, it is present in all sequences shown to bind to LexA1 in serovar Copenhageni. Almost every peak of LexA1 binding is located upstream of a gene, in potential regulatory regions. LexA1-bound genes show decreased or no differential expression after DNA damage	Leptospira interrogans serovar Copenhageni LT2050	?	-	?

Synonyms

Synonyms	Comment	Organism
LexA1	-	Leptospira interrogans serovar Copenhageni
lexA_1	-	Leptospira interrogans serovar Copenhageni

General Information

General Information	Comment	Organism
physiological function	isozyme LexA1 is probably the main regulator of the SOS response in Leptospira interrogans. In addition to both lexA genes and their operons, recA, recN and dinP are LexA1-bound and induced by DNA damage. LexA1 binds to the upstream sequence of both lexA1 and lexA2. Global transcriptional profiling during UV-C DNA damage response, overview. Two prophages heavily induce 12 h after UV-C irradiation involving LexA1 binding. Determination of LexA1 SOS box and DNA damage-inducible LexA1-bound genes	Leptospira interrogans serovar Copenhageni

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Release 2023.1 (January 2023)