Literature summary for 3.4.21.88 extracted from

Erill, I.; Campoy, S.; Kilic, S.; Barbe, J.
The Verrucomicrobia LexA-binding motif insights into the evolutionary dynamics of the SOS response (2016), Front. Mol. Biosci., 3, 33 .

Search for more literature for 3.4.21.88

Cloned(Commentary)

Cloned (Comment)	Organism
gene lexA, comparative genomics and analysis of the core SOS regulon	Verrucomicrobia

Protein Variants

Protein Variants	Comment	Organism
additional information	site-directed mutagenesis of the Verrucomicrobium spinosum recA promoter confirms that LexA binds a 14 bp palindromic motif with consensus sequence TGTTC-N4-GAACA	Verrucomicrobia

Organism

Organism	UniProt	Comment	Textmining
Verrucomicrobia	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	LexA binds a 14 bp palindromic motif with consensus sequence TGTTC-N4-GAACA, computational analysis of the recognition motif, comparative genomics analysis. The Verrucomicrobia LexA protein targets tandem binding sites in LexA promoters	Verrucomicrobia	?	-	?

General Information

General Information	Comment	Organism
evolution	evolutionary dynamics of the SOS response involving the LexA enzyme, overview. The composition of the SOS genetic network and the binding motif of its transcriptional repressor, LexA, vary greatly across bacterial clades. Multiple sequence alignment of available LexA protein sequences for the phylum Verrucomicrobia, using the information in Escherichia coli LexA cyrstal structure (UniProt ID P0A7C2). The core Verrucomicrobia LexA regulon comprises three operons involved in DNA repair and mutagenesis, i.e. lexA, splB, and imuA-imuB-dnaE2. The Verrucomicrobia LexA regulon is highly variable and incorporates novel functions, overview	Verrucomicrobia
physiological function	the SOS response is the primary bacterial mechanism to address DNA damage, coordinating multiple cellular processes that include DNA repair, cell division, and translesion synthesis. In contrast to other regulatory systems, the composition of the SOS genetic network and the binding motif of its transcriptional repressor, LexA, vary greatly across bacterial clades	Verrucomicrobia

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Release 2023.1 (January 2023)