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Literature summary for 3.4.21.88 extracted from
- Nucleotide sequence of the lexA gene of E. coli (1981), Cell, 23, 689-697.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| RecA protein | RecA protein and single-stranded DNA are required for activity being attributed to a Ser/Lys dyad. The LexA protein represses the SOS regulon, which regulates the genes involved in DNA repair. In the presence of single-stranded DNA, the RecA protein interacts with repressor LexA, causing it to undergo an autocatalytic cleavage which disrupts the DNA-binding part of the repressor, and inactivates it. The consequent derepression of the SOS regulon leads to DNA repair | Escherichia coli |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
- |
Escherichia coli |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 22700 | - |
calculation from nucleotide sequence | Escherichia coli |
| 22700 | - |
E. coli | Escherichia coli |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Repressor LexA + H2O | - |
Escherichia coli | LexA cleavage products | - |
? |  |
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Release 2023.1 (January 2023)
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