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Literature summary for 3.4.21.79 extracted from

  • Arias, M.A.; Jimenez de Baguees, M.P.; Aguilo, N.; Menao, S.; Hervas-Stubbs, S.; de Martino, A.; Alcaraz, A.; Simon, M.M.; Froelich, C.J.; Pardo, J.
    Elucidating sources and roles of granzymes A and B during bacterial infection and sepsis (2014), Cell Rep., 8, 420-429.
    View publication on PubMed

Application

Application Comment Organism
medicine the protease may be a therapeutic target for the prevention of bacterial sepsis without affecting immune control of the pathogen Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus P04187 gene gzmB
-
Mus musculus B6 P04187 gene gzmB
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Mus musculus
-
macrophage
-
Mus musculus
-
natural killer cell
-
Mus musculus
-
spleen
-
Mus musculus
-

General Information

General Information Comment Organism
malfunction the mouse pathogen Brucella microti persists in mice lacking perforin or granzyme B as well as in mice depleted of Tc cells Mus musculus
physiological function the enzyme is required for elimination of the mouse pathogen Brucella microti from liver and spleen and is necessary to inhibit Brucella microti replication in primary macrophages Mus musculus