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Literature summary for 3.4.21.79 extracted from

  • Omoto, Y.; Yamanaka, K.; Tokime, K.; Kitano, S.; Kakeda, M.; Akeda, T.; Kurokawa, I.; Gabazza, E.C.; Tsutsui, H.; Katayama, N.; Yamanishi, K.; Nakanishi, K.; Mizutani, H.
    Granzyme B is a novel interleukin-18 converting enzyme (2010), J. Dermatol. Sci., 59, 129-135.
    View publication on PubMed
Search for more literature for 3.4.21.79

Cloned(Commentary)

Cloned (Comment) Organism
commercial preparation Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
benzyloxycarbonyl-Ala-Ala-Asp-chloromethylketone GrB-specific inhibitor. Addition completely blocks reaction with interleukin proIL-18 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
interleukin proIL-18 + H2O Homo sapiens
-
 interleukin IL-18 + ? cleavage at residues D35-Y36 of proIL-18, identical to cleavage site of caspase-1 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
commercial preparation
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
interleukin proIL-18 + H2O
-
 Homo sapiens interleukin IL-18 + ? cleavage at residues D35-Y36 of proIL-18, identical to cleavage site of caspase-1 ?

General Information

General Information Comment Organism
physiological function GrB is a potent IL-18 converting enzyme. GrB secreted by CTLs and/or NK cells may initiate IL-18 release from target cells, leading to the development of inflammation Homo sapiens