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Literature summary for 3.4.21.79 extracted from

  • Chaitanya, G.V.; Eeka, P.; Munker, R.; Alexander, J.S.; Babu, P.P.
    Role of cytotoxic protease granzyme-b in neuronal degeneration during human stroke (2011), Brain Pathol., 21, 16-30.
    View publication on PubMed

Application

Application Comment Organism
medicine ischemic brain samples after stroke contain significantly higher levels of Gra-b and interferon-gamma inducible protein-10 than non-ischemic controls. In stroke, poly(ADP-ribose) polymerase-1 and heat shock protein-70 are cleaved to canonical proteolytic signature fragments by Gra-b. Gra-b also binds to Bid and caspase-3 and colocalizesw with Annexin-V+/TUNEL+ in degenerating neurons. Gra-b inhibition protects both normal and ischemia-reperfused neurons against in vitro neurotoxicity mediated by activated CG-SH cells and supernatants. Increased leukocyte infiltration and elevated Gra-b levels in the post-stroke brain can induce contact-dependent and independent post-ischemic neuronal death to aggravate stroke injury Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Source Tissue

Source Tissue Comment Organism Textmining
brain in stroke samples, Gra-b co-localizes with Annexin-V+/TUNEL+ in degenerating neurons Homo sapiens
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Synonyms

Synonyms Comment Organism
Gra-b
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Homo sapiens