Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
endosome | both perforin and GzmB are endocytosed into giant endosomal antigen-1 endosomes that form after perforin treatment | Homo sapiens | 5768 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HeLa cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
granzyme B | - |
Homo sapiens |
Gzm | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | it is investigated how human perforin enhances GzmB uptake in the cell: perforin activates clathrin- and Dyn-dependent endocytosis to remove perforin from the plasma membrane and enhance GzmB uptake. Both perforin and GzmB are endocytosed into giant endosomal antigen-1 endosomes that form after PFN treatment. When endocytosis is inhibited, sublytic perforin or strptolysin-O becomes lytic, causing necrosis. Consequently, inhibiting clathrin or Dyn pathways shifts the balance of target cell death by GzmB and perforin from apoptosis to necrosis | Homo sapiens |