Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.21.79 extracted from

  • Thiery, J.; Keefe, D.; Saffarian, S.; Martinvalet, D.; Walch, M.; Boucrot, E.; Kirchhausen, T.; Lieberman, J.
    Perforin activates clathrin- and dynamin-dependent endocytosis, which is required for plasma membrane repair and delivery of granzyme B for granzyme-mediated apoptosis (2010), Blood, 115, 1582-1593.
    View publication on PubMedView publication on EuropePMC

Localization

Localization Comment Organism GeneOntology No. Textmining
endosome both perforin and GzmB are endocytosed into giant endosomal antigen-1 endosomes that form after perforin treatment Homo sapiens 5768
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
-
Homo sapiens
-

Synonyms

Synonyms Comment Organism
granzyme B
-
Homo sapiens
Gzm
-
Homo sapiens

General Information

General Information Comment Organism
physiological function it is investigated how human perforin enhances GzmB uptake in the cell: perforin activates clathrin- and Dyn-dependent endocytosis to remove perforin from the plasma membrane and enhance GzmB uptake. Both perforin and GzmB are endocytosed into giant endosomal antigen-1 endosomes that form after PFN treatment. When endocytosis is inhibited, sublytic perforin or strptolysin-O becomes lytic, causing necrosis. Consequently, inhibiting clathrin or Dyn pathways shifts the balance of target cell death by GzmB and perforin from apoptosis to necrosis Homo sapiens