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Literature summary for 3.4.21.79 extracted from

  • Chattopadhyay, P.K.; Betts, M.R.; Price, D.A.; Gostick, E.; Horton, H.; Roederer, M.; De Rosa, S.C.
    The cytolytic enzymes granyzme A, granzyme B, and perforin: expression patterns, cell distribution, and their relationship to cell maturity and bright CD57 expression (2009), J. Leukoc. Biol., 85, 88-97.
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Source Tissue

Source Tissue Comment Organism Textmining
additional information alphabeta T cell and gammabeta T cell express gA, gB and perforin simultaneously Homo sapiens
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natural killer cell natural killer cells expressing CD16, generally express gA, gB and perforin simultaneously Homo sapiens
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peripheral blood mononuclear cell cells that do not express either granzyme (gA- or gB-) rarely express perforin and generally express little or no CD57. Granzyme B is never expressed without granzyme A. gA- gB- cells can only express low levels of perforin, as high perforin content requires expression of gA and gB. Less differentiated, naive T cells express no cytotoxic enzymes (gA- gB- Perf-), and nearly all highly differentiated effector T cells (which are largely terminally differentiated CD57 bright cells) express the three cytotoxic enzymes simultaneously. The majority of CMV-specific T cells express gA, gB, and perforin, whereas EBV-specific T cells mostly express gA but not gB and HIV-specific T cells express gA, gB but low levels of perforin Homo sapiens
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Synonyms

Synonyms Comment Organism
gB
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 Homo sapiens