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Literature summary for 3.4.21.79 extracted from

  • Bratke, K.; Goettsching, H.; Kuepper, M.; Geyer, S.; Luttmann, W.; Virchow, J.C.
    Interleukin-4 suppresses the cytotoxic potential of in vitro generated, adaptive regulatory CD4(+) T cells by down-regulation of granzyme B (2008), Immunology, 127, 338-344.
    View publication on PubMedView publication on EuropePMC
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Activating Compound

Activating Compound Comment Organism Structure
additional information activation of CD4+ T cells with anti-CD3 and anti-CD28 or anti-CD46 induces granzyme B expression in all cells. Granzyme B expression in anti-CD3/anti-CD46 activated CD4+ T cells is much higher than granzyme B expression induced by usual activation (anti-CD3/anti-CD28) Homo sapiens

Application

Application Comment Organism
medicine granzyme B may be the limiting factor in adaptive regulatory T cell-mediated K562 target cell killing Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
EGTA
-
 Homo sapiens
interleukin-4 significantly suppresses granzyme B synthesis. Interleukin-4-mediated suppression of granzyme B leads to impaired cytotoxicity of adaptive regulatory T cells against K562 target cells Homo sapiens
z-AAD-chloromethylketone
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
additional information CD4+ adaptive regulatory T cells generated by co-ligation of CD3 and CD46 express high amounts of granzyme B Homo sapiens
-

Synonyms

Synonyms Comment Organism
GrB
-
 Homo sapiens