Literature summary for 3.4.21.79 extracted from

Takahashi, Y.; Mine, J.; Kubota, Y.; Yamazaki, E.; Fujiwara, T.
A substantial number of Rasmussen syndrome patients have increased IgG, CD4(+) T cells, TNFalpha, and granzyme B in CSF (2009), Epilepsia, 50, 1419-1431.

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Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	granzyme B level is elevated in the early stage of Rasmussen syndrome around the onset of epilepsy and remains slightly elevated even in the progressed stage, and declines within a few months to more or less constant levels	Homo sapiens

Application

Application	Comment	Organism
medicine	granzyme B level may contribute to a diagnosis of immune-mediated epilepsy including Rasmussen syndrome	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	no significant difference of granzyme B between patients without immunologic treatment and patients after introduction of immunologic treatment, this may be attributed to the variety of clinical stage at the introduction of immunologic treatment and the variety of immunologic treatment	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
cerebrospinal fluid	-	Homo sapiens	-
additional information	CD8+ T cell, granzyme B-secreting cell	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
GrB	-	Homo sapiens

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Release 2023.1 (January 2023)