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Literature summary for 3.4.21.79 extracted from

  • Waterhouse, N.J.; Trapani, J.A.
    H is for helper: granzyme H helps granzyme B kill adenovirus-infected cells (2007), Trends Immunol., 28, 373-375.
    View publication on PubMed
Search for more literature for 3.4.21.79

Activating Compound

Activating Compound Comment Organism Structure
additional information natural killer cells stimulated in vitro with interleukin-2 express progressively greater amounts of perforin and granzyme B Homo sapiens

Application

Application Comment Organism
medicine granzyme H participates in the anti-adenovirus response by both inhibiting virus replication directly and simultaneously re-sensitizing infected cell to granzyme B-induced cell death Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information mice deficient in granzyme B are up to 100000fold more sensitive to the natural mouse proxivirus pathogen ectromelia than are wild-type mice Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
L4-100k assembly protein acts as a sink that binds to and inhibits granzyme B, preventing target cell death Homo sapiens
additional information natural killer cells stimulated in vitro with interleukin-2 reduce their granzyme H levels over 3-4 days Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
granzyme H Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
cytotoxic T-lymphocyte cell line
-
 Homo sapiens
-
natural killer cell express high levels of granzyme H but relatively low levels of granzyme B Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
DNA binding protein + H2O granzyme B and granzyme H (cleavage at Met118 and Phe121) Homo sapiens ?
-
 ?
L4-100k assembly protein + H2O granzyme H Homo sapiens ?
-
 ?
additional information granzyme H does not cleave BID or inhibitor of caspase-activated death, does not activate caspases Homo sapiens ?
-
 ?
pro-caspase-3 + H2O granzyme B Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
Granzyme H
-
 Homo sapiens