Literature summary for 3.4.21.79 extracted from

Packard, B.Z.; Telford, W.G.; Komoriya, A.; Henkart, P.A.
Granzyme B activity in target cells detects attack by cytotoxic lymphocytes (2007), J. Immunol., 179, 3812-3820.

Search for more literature for 3.4.21.79

Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	no GzB activity in CTL or NK92 effector cells, but activity rapidly becomes detectable throughout the target cytoplasm after effector-target engagement. Lack of GzB activity in Jurkat cells following intrinsic and extrinsic apoptotic stimuli	Homo sapiens

Application

Application	Comment	Organism
medicine	detection of target GzB activity followed by caspase 3 activation provides a unique readout of a potentially lethal injury delivered by cytotoxic lymphocytes	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
additional information	CD8+ T cell	Homo sapiens	-
additional information	no GzB activity in CTL or NK92 effector cells. Lack of GzB activity in Jurkat cells	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
VGPDFGR + H2O	-	Homo sapiens	VGPD + FGR	-	?

Synonyms

Synonyms	Comment	Organism
GzB	-	Homo sapiens

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)