Application | Comment | Organism |
---|---|---|
medicine | GrB proteolysis of Hsc70/Hsp70-interacting protein is important to the efficiency of death induction | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Bcl-2-associated athano gene-1 + H2O | GrB proteolysis is independent of caspase activity | Homo sapiens | ? | - |
? | |
Hsc70/Hsp70-interacting protein + H2O | Hsc70/Hsp70-interacting protein is cleaved at both GrB cleavage sites (at sequences IEPD92-TD and INPD180-SA) during NK-mediated cell death in a caspase-independent manner. Hsc70/Hsp70-interacting protein is a substrate unique to GrB | Homo sapiens | ? | - |
? | |
Hsp70/Hsp90-organizing protein + H2O | - |
Homo sapiens | ? | - |
? | |
Hsp90 + H2O | is proteolyzed at multiple sites by GrB. Cleavage at sequences IDED693-EV and INPD631-PI in Hsp90beta. Cleavage at sequences IDED701-DP, INPD639-HS and VRTD175-TG in Hsp90alpha | Homo sapiens | ? | - |
? | |
additional information | Hsp27 is resistant to GrB proteolysis | Homo sapiens | ? | - |
? | |
poly(ADP-ribose) polymerase + H2O | - |
Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
GrB | - |
Homo sapiens |