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Literature summary for 3.4.21.79 extracted from

  • Bredemeyer, A.J.; Carrigan, P.E.; Fehniger, T.A.; Smith, D.F.; Ley, T.J.
    Hop cleavage and function in granzyme B-induced apoptosis (2006), J. Biol. Chem., 281, 37130-37141.
    View publication on PubMed
Search for more literature for 3.4.21.79

Application

Application Comment Organism
medicine Hsp70/Hsp90-organizing protein per se does not set the threshold for susceptibility to GzmB-induced apoptosis Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information target cells with reduced levels of Hsp70/Hsp90-organizing protein are no more susceptible than control target cells to GzmB-/-/deltaPGK-neo and GzmB-/-/+PGK-neo natural killer effectors. GzmA-/- x GzmB-/-/deltaPGK-neo and GzmA-/- x GzmB-/-/+PGK-neo doubly deficient natural killer effectors, likewise, show no differences in susceptibility between control and Hsp70/Hsp90-organizing protein knockdown target cells Mus musculus

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
additional information YAC-1 cell Mus musculus
-
natural killer cell
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
alpha-tubulin
-
 Mus musculus ?
-
 ?
Hsp70/Hsp90-organizing protein + H2O
-
 Homo sapiens ?
-
 ?
Hsp70/Hsp90-organizing protein + H2O directly cleaved at Asp186 in vitro and in cells undergoing GzmB-induced death. Processing by GzmB is caspase-independent. Cleavage by GzmB destroys known functions of Hsp70/Hsp90-organizing protein in Hsp binding and hormone receptor assembly Mus musculus ?
-
 ?
additional information BID is not cleaved Mus musculus ?
-
 ?
pro-caspase-3 + H2O
-
 Mus musculus caspase-3 + ?
-
 ?

Synonyms

Synonyms Comment Organism
GzmB
-
 Mus musculus
GzmB
-
 Homo sapiens