Literature summary for 3.4.21.79 extracted from

Blink, E.J.; Jiansheng, Z.; Hu, W.; Calanni, S.T.; Trapani, J.A.; Bird, P.I.; Jans, D.A.
Interaction of the nuclear localizing cytolytic granule serine protease granzyme B with importin alpha or beta: modulation by the serpin inhibitor PI-9 (2005), J. Cell. Biochem., 95, 598-610.

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Inhibitors

Inhibitors	Comment	Organism	Structure
serpin inhibitor PI-9	granzyme B specific serpin inhibitor, complexation of enzyme with inhibitor prevents recognition by receptor importin beta and eliminates requirement of importin alpha for nuclear import	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
nucleus	for nuclear import, receptor importin alpha is required, while receptor importin beta inhibits import	Homo sapiens	5634	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Subunits

Subunits	Comment	Organism
More	enzyme interacts with either of the nuclear import receptor family members importin alpha and beta, but in addition exogenous cytosol is required for nuclear import of enzyme	Homo sapiens

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Release 2023.1 (January 2023)