Protein Variants | Comment | Organism |
---|---|---|
Q48R/P88A/Y245H | common allele termed RAH, mutant enzmye has essentially identical proteolytic and cytotoxic properties to wild-type | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0057 | - |
Abz-IEPDSSMESK-DNP | mutant Q48R/P88A/Y245H, 37°C | Homo sapiens | |
0.0058 | - |
Abz-IEPDSSMESK-DNP | wild-type, 37°C | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
encoded by RAH allele | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
29 | - |
native wild-type, 37°C | Homo sapiens |
82 | - |
recombinant wild-type, 37°C | Homo sapiens |
131 | - |
mutant Q48R/P88A/Y245H, 37°C | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Abz-IEPDSSMESK-2,4-dinitrophenyl + H2O | - |
Homo sapiens | ? | - |
? | |
Abz-IEPDSSMESK-DNP + H2O | - |
Homo sapiens | ? | - |
? |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
4.4 | - |
Abz-IEPDSSMESK-2,4-dinitrophenyl | wild-type, 37°C | Homo sapiens | |
4.6 | - |
Abz-IEPDSSMESK-2,4-dinitrophenyl | mutant Q48R/P88A/Y245H, 37°C | Homo sapiens |