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Literature summary for 3.4.21.79 extracted from

  • Van de Craen, M.; Van den Brande, I.; Declercq, W.; Irmler, M.; Beyaert, R.; Tschopp, J.; Fiers, W.; Vandenabeele, P.
    Cleavage of caspase family members by granzyme B. A comparative study in vitro (1997), Eur. J. Immunol., 27, 1296-1299.
    View publication on PubMed
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus involved in cell killing by cytotoxic T lymphocytes, activates the apoptotic death pathway in the target cell ?
-
 ?
pro-mCASP-3 + H2O Mus musculus activational cleavage of the caspase proform caspase-3 + ?
-
 ?
pro-mCASP-7 + H2O Mus musculus activational cleavage of the caspase proform caspase-7 + ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 mouse
-

Purification (Commentary)

Purification (Comment) Organism
-
 Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information involved in cell killing by cytotoxic T lymphocytes, activates the apoptotic death pathway in the target cell Mus musculus ?
-
 ?
additional information proforms of mCASP-2 and mCASP-1 are not substrates, pro-mCASP-6 is not proteolytically cleaved by granzyme B, mCASP-11 and mCASP-12 are not processed Mus musculus ?
-
 ?
pro-mCASP-3 + H2O activational cleavage of the caspase proform Mus musculus caspase-3 + ?
-
 ?
pro-mCASP-7 + H2O activational cleavage of the caspase proform Mus musculus caspase-7 + ?
-
 ?